根据运动心肌单光子发射计算机断层扫描，短暂性缺血性扩张率（TID）与确诊为心肌缺血的2型糖尿病患者的糖化血红蛋白（HbA1c）相关。

Transient ischemic dilation ratio (TID) correlates with HbA(1c) in patients with diabetes type 2 with proven myocardial ischemia according to exercise myocardial SPECT.

作者信息

Adamikova Alena, Bakala Jiri, Bernatek Jaromir, Rybka Jaroslav, Svacina Stepan

机构信息

Diabetes Center, WHO Collaborating Center for the Study of Diabetes, Bata Regional Hospital, Zlín, Czech Republic.

出版信息

Ann Nucl Med. 2006 Nov;20(9):615-21. doi: 10.1007/BF02984659.

DOI:10.1007/BF02984659

PMID:17294672

Abstract

OBJECTIVE

Abnormal values of the transient ischemic dilation ratio (TID) according to an exercise myocardial SPECT are linked to severe coronary artery disease. The authors investigated the relationship between TID and the levels of VCAM, ICAM, E-selectin, microalbuminuria, intima-media thickness and HbA(1c) of diabetic subjects.

METHODS

We observed 38 subjects with diabetes type 2 (10 women, 28 men), of average age 56.08 +/- 8.24 years, with no past history of cardiovascular disease. All subjects were examined using an exercise myocardial SPECT. Transient ischemic dilation, summed stress score (SSS), summed rest score (SRS) and stress total severity score (STSS) were determined to quantify myocardial ischemia.

RESULTS

The average IMT value was 1.05 +/- 0.31 mm. The TID value was 1.02 +/- 0.154, VCAM 795.24 +/- 163.25 mg/l, ICAM 516.55 +/- 164.07, E-selectin 63.82 +/- 38.89, HbA(1c) 7.09 +/- 1.68%, microalbuminuria 68.01 +/- 55.21 mg/l. When ascertaining the relation of TID to the other factors we used Pearson's correlation at the level of significance p < 0.05. We proved a statistically significant correlation between the value of TID and glycosylated hemoglobin HbA(1c) (p = 0.035); the other factors did not show any significant correlation.

CONCLUSION

Diabetes and its long- term unsatisfactory compensation can be one of the factors which affect left ventricular transient ischemic dilation.

摘要

目的

运动心肌单光子发射计算机断层扫描（SPECT）的短暂性缺血扩张率（TID）异常值与严重冠状动脉疾病相关。作者研究了糖尿病患者的TID与血管细胞黏附分子（VCAM）、细胞间黏附分子（ICAM）、E-选择素、微量白蛋白尿、内膜中层厚度和糖化血红蛋白（HbA₁c）水平之间的关系。

方法

我们观察了38例2型糖尿病患者（10名女性，28名男性），平均年龄56.08±8.24岁，无心血管疾病病史。所有受试者均接受运动心肌SPECT检查。测定短暂性缺血扩张、总负荷评分（SSS）、总静息评分（SRS）和负荷总严重程度评分（STSS）以量化心肌缺血。

结果

平均内膜中层厚度（IMT）值为1.05±0.31毫米。TID值为1.02±0.154，VCAM为795.24±163.25毫克/升，ICAM为516.55±164.07，E-选择素为63.82±38.89，HbA₁c为7.09±1.68%，微量白蛋白尿为68.01±55.21毫克/升。在确定TID与其他因素的关系时，我们使用了显著性水平p<0.05的Pearson相关性分析。我们证明TID值与糖化血红蛋白HbA₁c之间存在统计学显著相关性（p=0.035）；其他因素未显示任何显著相关性。