Hasegawa Tadashi
Department of Surgical Pathology, Sapporo Medical University School of Medicine, South 1 West 16 Chuo-ku, Sapporo 060-8543, Japan.
Pathol Int. 2007 Mar;57(3):121-5. doi: 10.1111/j.1440-1827.2006.02068.x.
Soft-tissue sarcomas or malignant soft-tissue tumors are malignant tumors arising from soft tissues of mesenchymal origin. These soft-tissue tumors can develop from any site in the body, including the extremities, trunk, retroperitoneum, or the head/neck region. In Japan, soft-tissue sarcomas are rarely encountered, with an incidence of approximately 2 per 100 000 population. Diverse types (more than 30 types) of soft-tissue sarcomas are known. Pathological examination of biopsy or resected specimens is indispensable for a definitive diagnosis of soft-tissue sarcomas. Needless to say, early detection and treatment based on accurate diagnosis are the basic principles of the management of soft-tissue sarcomas. The purpose of the present paper was to address the histological grading of soft-tissue sarcomas (the most important histopathological prognostic factor for this type of sarcoma) based on the French Fédération Nationale des Centres de Lutte Contre Ie Cancer (FNCLCC) system, the histological grading of this type of sarcoma based on the MIB-1 labeling index (an immunohistochemical marker of cell proliferation; MIB-1 system), precautions that must be taken while evaluating the degree of malignancy and the relationship of the grade with other clinicopathological factors.
软组织肉瘤或恶性软组织肿瘤是起源于间充质的软组织产生的恶性肿瘤。这些软组织肿瘤可发生于身体的任何部位，包括四肢、躯干、腹膜后或头/颈部区域。在日本，软组织肉瘤很少见，发病率约为每10万人中有2例。已知有多种类型（超过30种）的软组织肉瘤。活检或切除标本的病理检查对于软组织肉瘤的明确诊断必不可少。不用说，基于准确诊断的早期发现和治疗是软组织肉瘤治疗的基本原则。本文的目的是基于法国国家癌症防治中心联合会（FNCLCC）系统阐述软组织肉瘤的组织学分级（这类肉瘤最重要的组织病理学预后因素）、基于MIB-1标记指数（一种细胞增殖的免疫组化标志物；MIB-1系统）的这类肉瘤的组织学分级、评估恶性程度时必须采取的预防措施以及分级与其他临床病理因素的关系。
