Aalto-Korte Kristiina, Alanko Kristiina, Henriks-Eckerman Maj-Len, Kuuliala Outi, Jolanki Riitta
Control of Hypersensitivity Diseases Team, Finnish Institute of Occupational Health (FIOH), Helsinki FI-00250, Finland.
Contact Dermatitis. 2007 Mar;56(3):160-3. doi: 10.1111/j.1600-0536.2007.01033.x.
2-N-octyl-4-isothiazolin-3-one (OIT) is an antimicrobial agent that is mainly used in industrial settings. The objective of the study was to find the significance of OIT contact allergy at our clinic of occupational dermatology. We looked through our patient material from 1991 for allergic reactions to OIT and analysed the clinical records. We found 8 patients with ordinary allergic reactions to OIT and 1 late reaction. 2 workers in the manufacture of paints had occupational allergic contact dermatitis from OIT in biocides. 2 patients were machinists and 3 were female farmers: in these cases, however, we could not find any exposure. A sewing machine operator had patch test reactions to 2 of her mattress textiles, and chemical analysis of them showed 40-50 parts per million OIT. In conclusion, OIT is a rare sensitizer, and its contact allergies occur mainly in paint manufacturing. It is infrequently used in metal-working fluids and possibly sensitizes machinists. Although it is also used in some biocides recommended for use in the textile industry, there are no previous reports of contact allergy in this field. Our sewing machine operator with OIT contact allergy had probably been sensitized from mattress textiles.
2-正辛基-4-异噻唑啉-3-酮（OIT）是一种主要用于工业环境的抗菌剂。本研究的目的是确定OIT接触性过敏在我们职业皮肤病诊所中的意义。我们查阅了1991年以来的患者资料，以查找对OIT的过敏反应，并分析了临床记录。我们发现8例对OIT有普通过敏反应，1例迟发性反应。2名油漆制造工人因接触含有OIT的杀生物剂而患职业性过敏性接触性皮炎。2例患者是机械师，3例是女性农民：然而，在这些病例中，我们未发现任何接触情况。一名缝纫机操作员对她床垫中的两种纺织品进行斑贴试验呈阳性反应，对其进行化学分析显示其中含有百万分之40 - 50的OIT。总之，OIT是一种罕见的致敏剂，其接触性过敏主要发生在油漆制造行业。它很少用于金属加工液中，可能会使机械师致敏。虽然它也用于一些推荐在纺织工业中使用的杀生物剂，但此前该领域尚无接触性过敏的报道。我们这位患有OIT接触性过敏的缝纫机操作员可能是因床垫纺织品而致敏。
