伊朗母亲及其新生儿的维生素D状况。
Vitamin D status in mothers and their newborns in Iran.
作者信息
Maghbooli Zhila, Hossein-Nezhad Arash, Shafaei Ali Reza, Karimi Farzaneh, Madani Farzaneh Sadat, Larijani Bagher
机构信息
Endocrinology and Metabolism Research Center, Tehran University of Medical Sciences, 5th Floor, Shariati Hospital, North Kargar Avenue, Tehran 14114, Iran.
出版信息
BMC Pregnancy Childbirth. 2007 Feb 12;7:1. doi: 10.1186/1471-2393-7-1.
BACKGROUND
Adequate vitamin D concentrations during pregnancy are necessary to neonatal calcium homeostasis, bone maturation and mineralization. The aim of study is to evaluate serum vitamin D concentrations in mothers and their newborns and effect of vitamin D deficiency on pregnancy outcomes.
METHODS
552 pregnant women were recruited from Tehran University educating hospitals in the winter of 2002. Maternal and cord blood samples were taken at delivery. The serum was assayed for 25-hydroxyvitamin D3, calcium, phosphorus and parathyroid hormone.
RESULTS
The prevalence of vitamin D deficiency in maternal and cord blood samples were 66.8% and 93.3%, respectively (<35 nmol/l). There was significant correlation between maternal and cord blood serum concentrations of vitamin D. In mothers with vitamin D deficiency, cord blood vitamin D concentrations was lower than those from normal mothers (P = .001). Also, a significant direct correlation was seen between maternal vitamin D intake and weight gain during pregnancy.
CONCLUSION
Consideration to adequate calcium and vitamin D intake during pregnancy is essential. Furthermore, we think it is necessary to reconsider the recommendation for vitamin D supplementation for women during pregnancy.
背景
孕期充足的维生素D浓度对新生儿钙稳态、骨骼成熟和矿化至关重要。本研究的目的是评估母亲及其新生儿的血清维生素D浓度以及维生素D缺乏对妊娠结局的影响。
方法
2002年冬季，从德黑兰大学教学医院招募了552名孕妇。在分娩时采集母血和脐带血样本。检测血清中的25-羟基维生素D3、钙、磷和甲状旁腺激素。
结果
母血和脐带血样本中维生素D缺乏的患病率分别为66.8%和93.3%（<35 nmol/l）。母血和脐带血血清维生素D浓度之间存在显著相关性。维生素D缺乏的母亲，其脐带血维生素D浓度低于正常母亲（P = .001）。此外，母亲维生素D摄入量与孕期体重增加之间存在显著的正相关。
结论
孕期考虑摄入充足的钙和维生素D至关重要。此外，我们认为有必要重新考虑孕期妇女维生素D补充的建议。
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