Michel Tanja Maria, Frangou Sophia, Thiemeyer Dorothea, Camara Sibylle, Jecel Julia, Nara Keinosuke, Brunklaus Andreas, Zoechling Robert, Riederer Peter
Clinical Neurochemistry, Department Psychiatry and Psychotherapy, University Hospital Würzburg, Fürchsleinstr. 15, 97080 Würzburg, Germany.
Psychiatry Res. 2007 May 30;151(1-2):145-50. doi: 10.1016/j.psychres.2006.04.013. Epub 2007 Feb 12.
Prefrontal cortical (PFC) and hippocampal (HI) volume reductions have been consistently found in patients with recurrent depressive disorder (DD). Here we examine the possibility that oxidative stress, widely implicated in neuronal cell damage, may contribute to these brain structural changes. We compared manganese (Mn) and copper/zinc (Cu/Zn) superoxide dismutase (SOD) coenzyme concentrations in postmortem PFC and hippocampal brain tissue from 7 patients with DD and 7 neuropsychiatrically healthy controls using sandwich-type enzyme-linked immunosorbent assay (ELISA) technique. The concentration of Cu/Zn-SOD was significantly increased in the PFC but not in the hippocampus of patients. There was no significant change in Mn-SOD enzyme concentration in either region. Our findings contribute to the growing body of evidence implicating oxidative stress in the pathophysiology of depressive disorder.
复发性抑郁症（DD）患者的前额叶皮质（PFC）和海马体（HI）体积减少已被反复证实。在此，我们研究了广泛涉及神经元细胞损伤的氧化应激可能导致这些脑结构变化的可能性。我们使用夹心型酶联免疫吸附测定（ELISA）技术，比较了7例DD患者和7例神经精神健康对照者死后PFC和海马脑组织中锰（Mn）和铜/锌（Cu/Zn）超氧化物歧化酶（SOD）辅酶浓度。患者的PFC中Cu/Zn-SOD浓度显著升高，但海马体中未升高。两个区域的Mn-SOD酶浓度均无显著变化。我们的研究结果为越来越多的证据表明氧化应激参与抑郁症的病理生理学提供了支持。
