Simoni-Wastila Linda, Yang Huiwen Keri
Long-term Care Initiative, Peter Lamy Center on Drug Therapy and Aging, School of Pharmacy, University of Maryland Baltimore, Baltimore, Maryland 21201, USA.
Am J Geriatr Pharmacother. 2006 Dec;4(4):380-94. doi: 10.1016/j.amjopharm.2006.10.002.
Misuse and abuse of legal and illegal drugs constitute a growing problem among older adults.
This article reviews the prevalence, risks and protective factors, and screening and diagnosis of drug abuse in older adults. Treatment concerns and the consequences of drug problems are examined briefly.
MEDLINE and PsychInfo were searched using the terms substance-related disorders, drug-use disorders, abuse, dependency, opioid-related disorders, stimulant-related disorders, cocaine-related disorders, marijuana-related disorders, and withdrawal syndrome. The review included articles published in English between January 1, 1990, and May 31, 2006.
Despite a wealth of information on the epidemiology and treatment of alcohol abuse in older adults, few comparable data are available on drug abuse in this population. The evidence suggests that although illegal drug use is relatively rare among older adults compared with younger adults and adolescents, there is a growing problem of the misuse and abuse of prescription drugs with abuse potential. It is estimated that up to 11% of older women misuse prescription drugs and that nonmedical use of prescription drugs among all adults aged > or =50 years will increase to 2.7 million by the year 2020. Factors associated with drug abuse in older adults include female sex, social isolation, history of a substance-use or mental health disorder, and medical exposure to prescription drugs with abuse potential. No validated screening or assessment instruments are available for identifying or diagnosing drug abuse in the older population. Special approaches may be necessary when treating substance-use disorders in older adults with multiple comorbidities and/or functional impairment, and the least intensive approaches should be considered first.
Psychoactive medications with abuse potential are used by at least 1 in 4 older adults, and such use is likely to grow as the population ages. The treatment of disorders of prescription drug use in older adults may involve family and caretakers, and should take into account the unique physical, emotional, and cognitive factors of aging. Further research is needed on the epidemiologic, health services, and treatment aspects of drug abuse in older adults, as well as the development of appropriate screening and diagnostic tools.
合法及非法药物的滥用在老年人中已成为一个日益严重的问题。
本文综述老年人药物滥用的患病率、风险及保护因素,以及筛查与诊断情况。简要探讨治疗相关问题及药物问题的后果。
使用“物质相关障碍”“药物使用障碍”“滥用”“依赖”“阿片类相关障碍”“兴奋剂相关障碍”“可卡因相关障碍”“大麻相关障碍”及“戒断综合征”等检索词在MEDLINE和PsychInfo数据库中进行检索。本综述纳入了1990年1月1日至2006年5月31日期间发表的英文文章。
尽管有大量关于老年人酒精滥用的流行病学及治疗信息,但关于该人群药物滥用的可比数据却很少。证据表明,与年轻人和青少年相比,老年人中非法药物使用相对较少,但具有滥用潜力的处方药滥用及误用问题却日益严重。据估计,高达11%的老年女性会误用处方药,到2020年,所有年龄≥50岁成年人中的非医疗用处方药人数将增至270万。与老年人药物滥用相关的因素包括女性、社会孤立、物质使用或精神健康障碍史,以及有潜在滥用可能的处方药的医疗暴露史。目前尚无经过验证的筛查或评估工具可用于识别或诊断老年人群中的药物滥用情况。在治疗患有多种合并症和/或功能障碍的老年人的物质使用障碍时,可能需要采取特殊方法,且应首先考虑强度最低的方法。
至少四分之一的老年人使用有滥用潜力的精神活性药物,且随着人口老龄化,此类使用可能会增加。老年人处方药使用障碍治疗可能涉及家庭和照料者,且应考虑到衰老所特有的身体、情感和认知因素。需要进一步研究老年人药物滥用的流行病学、卫生服务及治疗方面,以及开发合适的筛查和诊断工具。