Nemati Ahmad, Dadpour Bita, Etemad Leila, Mousavi Seyed Reza, Alizadeh Ghomsari Anahita, Mousavi Seyed Hadi, Ghasemi-Toosi Alireza, Kimiafar Khalil, Ataee Zahra, Vahabzadeh Maryam, Zarifkia Shiva, Khoshbakht Reza, Khoshrou Alireza, Salmani Izadi Hanie, Moshiri Mohammad
Student Research Committee, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
Medical Toxicology Research Center, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.
J Prev (2022). 2025 Feb;46(1):103-120. doi: 10.1007/s10935-024-00804-z. Epub 2024 Sep 9.
This study aimed to assess the risk factors and clinical-epidemiological patterns of acute poisoning among elderly individuals to guide prevention strategies. The epidemiological, clinical data, manner and cause of poisoning, and outcome of the registered elder cases (≥ 60 years old) in the clinical toxicology department of Imam Reza Hospital of Mashhad University of Medical Silences (CTD-IRH-MUMS) were investigated for nine months. The sex and age distribution of the patients were compared with the general population of Khorasan-Razavi using direct standardization. Among the 3064 cases registered at the hospital, 124 elderly patients were included in the study. The majority (71.8%) were male, with a mean age of 69.47. Male gender was found to be a significant risk factor for poisoning among elderly individuals compared to the general population (OR = 2.62) (1.55-4.42) (p-value < 0.001), however, it was not significant for age. Substance dependency, particularly on opiates, was common among the patients (56.5%), with a higher prevalence in males. Substance overdose (35.4%) and suicide (23.3%) were the most common methods of poisoning, with varying frequencies between genders (p-value = 0.002). Male gender was identified as a risk factor for opiate intoxication (OR = 4.68, CI = 1.70-11.83, p-value < 0.05) but not for suicide attempts. The average hospital stay duration was similar between male and female patients. The mean length of hospital stay was 3.53 ± 4.02 days (median = 3.0, range = 0.5-26 days) and was similar in both sexes. In conclusion, male gender and opiate dependency were highlighted as key factors in the poisoning of elderly individuals. These findings emphasize the importance of addressing these factors in preventive measures.
本研究旨在评估老年个体急性中毒的危险因素及临床流行病学模式，以指导预防策略。对马什哈德医科大学伊玛目礼萨医院临床毒理学部（CTD - IRH - MUMS）登记的老年病例（≥60岁）进行了为期九个月的调查，内容包括流行病学、临床数据、中毒方式和原因以及结局。采用直接标准化方法，将患者的性别和年龄分布与霍拉桑 - 拉扎维省的普通人群进行比较。在医院登记的3064例病例中，124例老年患者纳入本研究。大多数（71.8%）为男性，平均年龄为69.47岁。与普通人群相比，男性被发现是老年个体中毒的一个重要危险因素（OR = 2.62）（1.55 - 4.42）（p值<0.001），然而，年龄因素并不显著。物质依赖，尤其是对阿片类药物的依赖，在患者中很常见（56.5%），男性患病率更高。药物过量（35.4%）和自杀（23.3%）是最常见的中毒方式，不同性别之间频率有所不同（p值 = 0.002）。男性被确定为阿片类药物中毒的危险因素（OR = 4.68，CI = 1.70 - 11.83，p值<0.05），但不是自杀未遂的危险因素。男性和女性患者的平均住院时间相似。平均住院时间为3.53±4.02天（中位数 = 3.0，范围 = 0.5 - 26天），两性相似。总之，男性性别和阿片类药物依赖被强调为老年个体中毒的关键因素。这些发现强调了在预防措施中解决这些因素的重要性。
