t(8;16)(p11;p13)急性髓系白血病中的新型MYST3-CBP和CBP-MYST3融合转录本

New types of MYST3-CBP and CBP-MYST3 fusion transcripts in t(8;16)(p11;p13) acute myeloid leukemias.

作者信息

Murati Anne, Adélaïde José, Quilichini Benoît, Rémy Virginie, Sainty Danielle, Stoppa Anne-Marie, Bernard Philippe, Olschwang Sylviane, Birnbaum Daniel, Chaffanet Max, Mozziconacci Marie-Joëlle

出版信息

Haematologica. 2007 Feb;92(2):262-3. doi: 10.3324/haematol.10744.

DOI:10.3324/haematol.10744

PMID:17296583

Abstract

The t(8;16)(p11;p13) translocation, associated with poor prognosis acute monocytic leukemia, fuses MYST3 on chromosome region 8p11 to CBP on chromosome region 16p13. Two types of MYST3-CBP and CBP-MYST3 fusion transcripts have been identified in patients. We describe two new types of MYST3-CBP transcripts and a new primer set.

摘要

与预后不良的急性单核细胞白血病相关的t(8;16)(p11;p13)易位，将8号染色体区域p11上的MYST3与16号染色体区域p13上的CBP融合。在患者中已鉴定出两种类型的MYST3-CBP和CBP-MYST3融合转录本。我们描述了两种新型的MYST3-CBP转录本和一套新的引物。