Oki Yasuhiro, Georgakis Georgios V, Migone Thi-Sau, Kwak Larry W, Younes Anas
Haematologica. 2007 Feb;92(2):269-70. doi: 10.3324/haematol.10678.
B-lymphocyte stimulator (BLyS) plays a critical role in the survival of B-lymphocytes. In 50 patients with Hodgkin's lymphoma BLyS levels were higher in newly diagnosed patients (median 2.0 ng/mL, range <0.3-56.0) and relapsed patients (8.7 ng/mL, range 1.5-71.5) than in 93 healthy donors (<0.3 ng/mL, range <0.3-0.5). High serum BLyS levels (> or =2.0 ng/mL) in newly diagnosed patients were associated with resistance to therapy (p=0.01) and shorter progression-free survival (log-rank p=0.029, 2-year rate 64% vs 100%). Serum BLyS levels may have prognostic significance in Hodgkin's lymphoma.
B淋巴细胞刺激因子（BLyS）在B淋巴细胞的存活中起关键作用。在50例霍奇金淋巴瘤患者中，新诊断患者（中位数2.0 ng/mL，范围<0.3 - 56.0）和复发患者（8.7 ng/mL，范围1.5 - 71.5）的BLyS水平高于93名健康供者（<0.3 ng/mL，范围<0.3 - 0.5）。新诊断患者中高血清BLyS水平（≥2.0 ng/mL）与治疗耐药相关（p = 0.01）且无进展生存期较短（对数秩检验p = 0.029，2年率64%对100%）。血清BLyS水平在霍奇金淋巴瘤中可能具有预后意义。
