胆汁盐刺激IpaB募集到福氏志贺菌表面，在那里它与III型分泌针尖端的IpaD共定位。

Bile salts stimulate recruitment of IpaB to the Shigella flexneri surface, where it colocalizes with IpaD at the tip of the type III secretion needle.

作者信息

Olive Andrew J, Kenjale Roma, Espina Marianela, Moore David S, Picking Wendy L, Picking William D

机构信息

Department of Molecular Biosciences, University of Kansas, 1200 Sunnyside Avenue, Lawrence, KS 66045, USA.

出版信息

Infect Immun. 2007 May;75(5):2626-9. doi: 10.1128/IAI.01599-06. Epub 2007 Feb 12.

DOI:10.1128/IAI.01599-06

PMID:17296762

原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC1865747/

Abstract

Shigella flexneri uses its type III secretion apparatus (TTSA) to deliver invasins into human cells. This TTSA possesses an external needle with IpaD at its tip. We now show that deoxycholate promotes the stable recruitment of IpaB to the needle tip without inducing a rapid burst of type III secretion. The maintenance of IpaB at the needle tip requires a stable association of IpaD with the Shigella surface. This is the first demonstration of a translocator protein being stably associated with the TTSA needle.

摘要

福氏志贺菌利用其三型分泌装置（TTSA）将侵袭素输送到人体细胞中。这种TTSA有一个外部针状结构，其尖端是IpaD。我们现在表明，脱氧胆酸盐可促进IpaB稳定募集到针状结构尖端，而不会引发三型分泌的快速爆发。IpaB在针状结构尖端的维持需要IpaD与志贺菌表面稳定结合。这是首次证明转运蛋白与TTSA针状结构稳定结合。