近期对 3 型分泌系统注入器结构和人类肠道病原体作用机制的深入了解。
Recent insights into type-3 secretion system injectisome structure and mechanism of human enteric pathogens.
机构信息
Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Microbiology, Harvard Medical School, Boston, MA, USA.
Division of Infectious Diseases, Department of Medicine, Massachusetts General Hospital, Boston, MA, USA; Department of Microbiology, Harvard Medical School, Boston, MA, USA; Broad Institute, Cambridge, MA, USA.
出版信息
Curr Opin Microbiol. 2023 Feb;71:102232. doi: 10.1016/j.mib.2022.102232. Epub 2022 Nov 9.
Abstract
Type-3 secretion system injectisomes are multiprotein complexes that translocate bacterial effector proteins from the cytoplasm of gram-negative bacteria directly into the cytosol of eukaryotic host cells. These systems are present in more than 30 bacterial species, including numerous human, animal, and plant pathogens. We review recent discoveries of structural and molecular mechanisms of effector protein translocation through the injectisomes and recent advances in the understanding of mechanisms of activation of effector protein secretion.
摘要
III 型分泌系统注射器是一种多蛋白复合物，可将革兰氏阴性菌细胞质中的细菌效应蛋白直接转运到真核宿主细胞的细胞质中。这些系统存在于 30 多种细菌中，包括许多人类、动物和植物病原体。我们回顾了最近关于效应蛋白通过注射器转运的结构和分子机制的发现，以及对效应蛋白分泌激活机制的理解的最新进展。
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