超越标准化：用于系统生物学的动态软件基础设施

Beyond standardization: dynamic software infrastructures for systems biology.

作者信息

Swertz Morris A, Jansen Ritsert C

机构信息

Groningen Bioinformatics Centre, Groningen Biomolecular Sciences and Biotechnology Institute, University of Groningen, Kerklaan 30, NL-9751 NN Haren, The Netherlands.

出版信息

Nat Rev Genet. 2007 Mar;8(3):235-43. doi: 10.1038/nrg2048. Epub 2007 Feb 13.

DOI:10.1038/nrg2048

PMID:17297480

Abstract

Progress in systems biology is seriously hindered by slow production of suitable software infrastructures. Biologists need infrastructure that easily connects to work that is done in other laboratories, for which standardization is helpful. However, the infrastructure must also accommodate the specifics of their biological system, but appropriate mechanisms to support variation are currently lacking. We argue that a minimal computer language, and a software tool called a generator, can be used to quickly produce customized software infrastructures that 'systems biologists really want to have'.

摘要

系统生物学的进展受到合适软件基础设施生产缓慢的严重阻碍。生物学家需要能够轻松连接到其他实验室所做工作的基础设施，标准化对此会有所帮助。然而，该基础设施还必须适应其生物系统的具体情况，但目前缺乏支持变异的适当机制。我们认为，一种最小化计算机语言和一种名为生成器的软件工具可用于快速生产出“系统生物学家真正想要拥有的”定制软件基础设施。