窄叶车前草提取物及一些分离化合物的解痉活性

Antispasmodic activity of an extract from Plantago lanceolata L. and some isolated compounds.

作者信息

Fleer H, Verspohl E J

机构信息

Institut für Pharmazeutische Biologie und Phytochemie der Westfälischen Wilhelms-Universität Münster, Hittorfstr. 56, 48149 Münster, Germany.

出版信息

Phytomedicine. 2007 Jun;14(6):409-15. doi: 10.1016/j.phymed.2006.05.006. Epub 2007 Feb 12.

DOI:10.1016/j.phymed.2006.05.006

PMID:17298877

Abstract

An ethanolic spissum extract of the aerial parts of Plantago lanceolata L. was examined for antispasmodic activity on isolated ileum and trachea of the guinea-pig. Isolated constituents were investigated as well. The P. lanceolata extract inhibited the contractions of the guinea-pig ileum that were induced by various agonists such as acetylcholine (ACh), histamine, potassium and barium ions. Additionally the trachea contractions induced by barium ions were inhibited. The compounds luteolin, acteoside, plantamajoside an catalpol peracetate but not catalpol, isoacteoside, lavandulifolioside and aucubin inhibited the ACh-induced contractions of the guinea-pig ileum. Luteolin and acteoside reduced the barium-induced contractions of the guinea-pig trachea. Two recently isolated compounds did not show antispasmodic activity: luteolin-3',7-diglucuronide and beta-hydroxy-acteoside.

摘要

对窄叶车前地上部分的乙醇浓缩提取物进行了豚鼠离体回肠和气管抗痉挛活性研究。同时也对分离出的成分进行了研究。窄叶车前提取物抑制了由各种激动剂如乙酰胆碱（ACh）、组胺、钾离子和钡离子诱导的豚鼠回肠收缩。此外，钡离子诱导的气管收缩也受到抑制。木犀草素、毛蕊花糖苷、大车前苷和过乙酸梓醇（而非梓醇）、异毛蕊花糖苷、薰衣草叶苷和桃叶珊瑚苷抑制了ACh诱导的豚鼠回肠收缩。木犀草素和毛蕊花糖苷降低了钡离子诱导的豚鼠气管收缩。最近分离出的两种化合物没有显示出抗痉挛活性：木犀草素-3',7-二葡萄糖醛酸苷和β-羟基毛蕊花糖苷。