González Alvarez R, Arruzazabala M L
Allergol Immunopathol (Madr). 1983 Nov-Dec;11(6):425-30.
Disodium cromoglycate (DSCG) (10(-2)M) significantly inhibits contractions induced by potassium chloride and barium chloride on guinea pig ileum and trachea. The effects of DSCG against these spasmogens are greater on the guinea pig ileum than on its trachea, which may be related with the calcium ion if we take into account that the contraction of the latter preparation seems to be less dependent on the extracellular calcium concentration than the first one. DSCG (10(-2)M) inhibits contractions induced by electrical stimulation (0.1 Hz) but the action of exogenous acetylcholine is not affected. This effect supports a neural site of action for DSCG in the ileum. DSCG (10(-2)M) also suppresses contractions induced by electrical stimulation (20 Hz) on isolated guinea pig trachea. This effect of DSCG is concentration and time dependent. The fact that DSCG inhibits contractions induced by electrical stimulation in both, guinea pig ileum and trachea as well as atropine does, constitute evidence that either an inhibition of acetylcholine release from postganglionic parasympathetic fibers or an anticholinergic effect is involved in the mode of action of DSCG. These effects can be ascribed to membrane stabilizing properties of this antiallergic drug.
色甘酸钠（DSCG）（10⁻²M）能显著抑制氯化钾和氯化钡对豚鼠回肠和气管的收缩作用。DSCG对这些致痉剂的作用在豚鼠回肠上比在气管上更强，考虑到气管制剂的收缩似乎比回肠制剂对细胞外钙浓度的依赖性更小，这种差异可能与钙离子有关。DSCG（10⁻²M）能抑制电刺激（0.1Hz）诱导的收缩，但对外源性乙酰胆碱的作用无影响。这一效应支持了DSCG在回肠中的作用位点是神经。DSCG（10⁻²M）也能抑制电刺激（20Hz）对离体豚鼠气管诱导的收缩。DSCG的这一效应具有浓度和时间依赖性。DSCG能像阿托品一样抑制豚鼠回肠和气管由电刺激诱导的收缩，这一事实表明，DSCG的作用方式涉及抑制节后副交感神经纤维释放乙酰胆碱或具有抗胆碱能效应。这些效应可归因于这种抗过敏药物的膜稳定特性。
