Schrotz-King P, Prokhorova T A, Nielsen P N, Crawford J S, Morsczeck C
ACE BioSciences, Drug Discovery, Unsbjergvej 2A, 5220 Odense, Denmark.
Travel Med Infect Dis. 2007 Mar;5(2):106-9. doi: 10.1016/j.tmaid.2006.01.019. Epub 2006 Jun 8.
Travellers' diarrhoea is defined as diarrhoea that develops while a person is abroad in or shortly after return from a developing country. Different pathogens cause diarrhoea in travellers. Campylobacter jejuni is one of the most prominent agents for this illness. Diarrhoea is defined as an abnormally increased frequency or decreased consistency of stools for less than one week. Antibiotics are effective in preventing travellers' diarrhoea, but routine prophylaxis with antibiotics, should be discouraged. Vaccination is promising but no vaccine against C. jejuni is available at the moment. This article presents the ACE BioSciences strategy for the discovery of protein based vaccine candidates using a cell surface proteomics approach of C. jejuni. New targets for C. jejuni protein vaccines were identified. As proof of concept, we could demonstrate decreased colonization of C. jejuni in mice after vaccination with some of these candidates. It is likely that the proteomics based ACE-Biosciences approach will result in reliable travellers' diarrhoea protein-vaccines in the future.
旅行者腹泻被定义为一个人在国外期间或从发展中国家返回后不久出现的腹泻。不同的病原体可导致旅行者腹泻。空肠弯曲菌是引发这种疾病的最主要病原体之一。腹泻被定义为排便频率异常增加或粪便稠度降低，持续时间少于一周。抗生素对预防旅行者腹泻有效，但不建议常规使用抗生素进行预防。疫苗接种前景广阔，但目前尚无针对空肠弯曲菌的疫苗。本文介绍了ACE生物科学公司利用空肠弯曲菌的细胞表面蛋白质组学方法发现基于蛋白质的候选疫苗的策略。确定了空肠弯曲菌蛋白质疫苗的新靶点。作为概念验证，我们可以证明用其中一些候选疫苗给小鼠接种后，空肠弯曲菌在小鼠体内的定植减少。基于蛋白质组学的ACE生物科学方法未来有可能产生可靠的旅行者腹泻蛋白质疫苗。
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