a Enteric Diseases Department , Naval Medical Research Center , Silver Spring , MD , USA.
b F. Edward Hébert School of Medicine , Uniformed Services University , Bethesda , MD , USA.
Hum Vaccin Immunother. 2019;15(6):1389-1400. doi: 10.1080/21645515.2018.1528410. Epub 2018 Oct 17.
: Acute diarrheal disease caused by viral, bacterial and parasitic infections are a major global health problem with substantial mortality and morbidity in children under five years of age in lower and middle income countries. However, a number of these infections also impact large segments of populations in upper income countries, as well as individuals who travel overseas for work, business or pleasure. has been and continues to be a leading cause of disease burden globally across all income countries. : The aim of this review is to describe recent understanding in burden of disease, consider the current landscape of vaccine development, and address the challenges that need to be overcome. : Relevant data from the literature as well as clinical trials described in European and US registries were used to conduct this review. : Despite advances in population health, food security, improved sanitation, water quality and the reduction of poverty, infections continue to plague global populations. The emerging recognition of chronic health consequences attributed to this pathogen is changing the potential valuation of preventive interventions. Advancing development of new vaccines is a present opportunity and holds promise.
由病毒、细菌和寄生虫感染引起的急性腹泻病是一个全球性的主要健康问题，在中低收入国家，五岁以下儿童的死亡率和发病率都很高。然而，这些感染中的许多也会影响到高收入国家的大部分人群，以及因工作、商务或娱乐目的而前往海外的个人。轮状病毒一直是全球所有收入国家疾病负担的主要原因。本综述的目的是描述疾病负担的最新认识，考虑当前轮状病毒疫苗开发的现状，并解决需要克服的挑战。本综述使用了来自文献和欧洲及美国登记处描述的临床试验的相关数据。尽管在人口健康、食品安全、改善卫生条件、水质和减少贫困方面取得了进展，但轮状病毒感染仍在困扰着全球人口。人们逐渐认识到这种病原体导致的慢性健康后果正在改变对预防干预措施的潜在评估。推进新疫苗的开发是目前的机会，前景看好。
