Gavi Shai, Stuart Louise M, Kelly Patricia, Melendez Mark M, Mynarcik Dennis C, Gelato Marie C, McNurlan Margaret A
Department of Medicine, Division of General Medicine and Geriatrics, School of Medicine, Health Sciences Center, State University of New York at Stony Brook, Stony Brook, NY 11794-8154, USA.
J Clin Endocrinol Metab. 2007 May;92(5):1886-90. doi: 10.1210/jc.2006-1815. Epub 2007 Feb 13.
Adipose tissue is responsible for releasing various adipokines that have been related to insulin resistance. Understanding the relationship of these adipokines to insulin resistance may foster the development of new treatments for diabetes.
The primary objective of this study was to determine whether an association between retinol-binding protein 4 (RBP4) and insulin resistance exists in nonobese individuals without a family history or diagnosis of diabetes. The secondary objective was to determine by a dual energy x-ray absorptiometry scan which adipose tissue depot most closely relates to RBP4 levels.
Cross-sectional analysis of 92 study participants ranging in age from 20 to 83 yr was performed. The range of body mass index (BMI) was from 18 to 30 kg/m(2). Exclusion criteria were a BMI greater than 30 kg/m(2), family history of diabetes, or a diagnosis of diabetes. Insulin sensitivity was determined by a hyperinsulinemic euglycemic clamp. Body fat was measured by dual energy x-ray absorptiometry scan.
RBP4 values were lower in females (35.8 +/- 1.7 microg/ml) compared with males (39.9 +/- 1.4 microg/ml; P = 0.06). RBP4 levels were found to correlate negatively with insulin sensitivity (r = -0.32; P = 0.002) and positively with age (r = 0.38; P < 0.001). RBP4 levels did not correlate with BMI (r = -0.13; P = 0.22), trunk fat (r = 0.16; P = 0.22), or percent body fat (r = 0.07; P = 0.65). However, RBP4 levels did correlate with percent trunk fat (r = 0.36; P = 0.001).
These findings indicate a relationship between RBP4, insulin sensitivity, and percent trunk fat in individuals who may not have features of insulin resistance.
脂肪组织负责释放多种与胰岛素抵抗相关的脂肪因子。了解这些脂肪因子与胰岛素抵抗之间的关系可能会促进糖尿病新疗法的开发。
本研究的主要目的是确定在无糖尿病家族史或未诊断出糖尿病的非肥胖个体中，视黄醇结合蛋白4（RBP4）与胰岛素抵抗之间是否存在关联。次要目的是通过双能X线吸收法扫描确定哪种脂肪组织储存库与RBP4水平最密切相关。
对92名年龄在20至83岁之间的研究参与者进行横断面分析。体重指数（BMI）范围为18至30kg/m²。排除标准为BMI大于30kg/m²、糖尿病家族史或糖尿病诊断。通过高胰岛素正常血糖钳夹法测定胰岛素敏感性。通过双能X线吸收法扫描测量身体脂肪。
女性的RBP4值（35.8±1.7μg/ml）低于男性（39.9±1.4μg/ml；P=0.06）。发现RBP4水平与胰岛素敏感性呈负相关（r=-0.32；P=0.002），与年龄呈正相关（r=0.38；P<0.001）。RBP4水平与BMI（r=-0.13；P=0.22）、躯干脂肪（r=0.16；P=0.22）或体脂百分比（r=0.07；P=0.65）均无相关性。然而，RBP4水平与躯干脂肪百分比呈正相关（r=0.36；P=0.001）。
这些发现表明，在可能没有胰岛素抵抗特征的个体中，RBP4、胰岛素敏感性和躯干脂肪百分比之间存在关联。
