Therrien Fanny, Drapeau Vicky, Lalonde Josée, Lupien Sonia J, Beaulieu Serge, Tremblay Angelo, Richard Denis
Department of Anatomy and Physiology, Laval University, Sainte-Foy, Quebec, Canada.
Obesity (Silver Spring). 2007 Feb;15(2):377-85. doi: 10.1038/oby.2007.509.
Our goal was to assess the awakening cortisol response (ACR) in obese and reduced obese men and women.
Fifty-one men (16 lean, 19 abdominally obese, and 16 reduced obese) and 31 women (12 lean, 10 subcutaneously obese, and 9 reduced obese) were selected to participate to this study. Strict ranges of BMI and waist circumference were used to select the participants. Medical examination, psychological assessment, anthropometric measurements, and blood sampling were undergone at the laboratory. Cortisol response to awakening was determined with saliva cortisol sampling being taken immediately at the time of awakening and 30 minutes thereafter over 3 days within a period of 2 months.
Men with visceral obesity exhibited an enhanced ACR, whereas this response tends to return to normal in a reduced obese state. In women, peripheral fat accumulation does not modify ACR, but weight loss increased the response.
These results highlight gender effects on ACR of obese and reduced obese subjects, which could be accounted for by the different fat distribution profiles that characterize men and women. They also provide further support for the usefulness of ACR in assessing the hypothalamic-pituitary-adrenal axis activity status.
我们的目标是评估肥胖及减重后的肥胖男性和女性的觉醒皮质醇反应（ACR）。
选取51名男性（16名瘦者、19名腹型肥胖者和16名减重后的肥胖者）和31名女性（12名瘦者、10名皮下肥胖者和9名减重后的肥胖者）参与本研究。采用严格的BMI和腰围范围来选取参与者。在实验室进行医学检查、心理评估、人体测量和血液采样。通过在觉醒时及之后30分钟立即采集唾液皮质醇样本，在2个月内的3天时间里测定皮质醇对觉醒的反应。
内脏型肥胖男性表现出增强的ACR，而在减重后的肥胖状态下这种反应趋于恢复正常。在女性中，外周脂肪堆积不会改变ACR，但体重减轻会增加该反应。
这些结果突出了性别对肥胖及减重后的肥胖受试者ACR的影响，这可能是由男性和女性不同的脂肪分布特征所致。它们还为ACR在评估下丘脑 - 垂体 - 肾上腺轴活动状态方面的有用性提供了进一步支持。
