Hamad Mawieh, Elkarmi Ali
Taif University School of Medicine, Saudi Arabia.
Riv Biol. 2006 Sep-Dec;99(3):483-97.
In an attempt to understand why different organisms defend against potential antigens differently, the influence of possible interactions between host-related factors and respective antigen repertoires on the complexity of host defense mechanisms was investigated. A compartmental model coupling these two variables was developed and tested. Data analysis suggests that the more complex the organism, the larger the size of its antigen repertoire. The two variables seem to advance in a parallel fashion suggesting that they could reach a state of equilibrium. Therefore, host-related factors may play a role in determining the size of the antigen repertoire on the one hand; on the other hand, increased antigen repertoire size may dictate the evolution of more complex mechanisms of immunity. Although the interplay between the two variables maintains some common themes in different groups of organisms, it results in clear differences pertinent to immunologic specificity, diversity, memory and self nonself discrimination.
为了理解为何不同生物体对潜在抗原的防御方式不同，研究了宿主相关因素与各自抗原库之间可能的相互作用对宿主防御机制复杂性的影响。开发并测试了一个将这两个变量耦合的区室模型。数据分析表明，生物体越复杂，其抗原库的规模就越大。这两个变量似乎以平行方式发展，表明它们可能会达到一种平衡状态。因此，宿主相关因素一方面可能在决定抗原库的规模方面发挥作用；另一方面，抗原库规模的增加可能决定更复杂免疫机制的进化。尽管这两个变量之间的相互作用在不同生物体群体中保持了一些共同特征，但它导致了在免疫特异性、多样性、记忆和自我非自我识别方面的明显差异。
