Vesteg Matej, Krajcovic Juraj, Ebringer Libor
Institute of Cell Biology, Faculty of Natural Sciences, Comenius University, Mlynska dolina, 842 15 Bratislava, Slovakia.
Riv Biol. 2006 Sep-Dec;99(3):499-519.
A novel hypothesis for the origin of eukaryotic cells is presented. It is assumed that the universal ancestor was bounded by two membranes of heterochiral lipid composition. We propose that the prokaryotic cells (the hypothetical host entity for alpha proteic-bacteria), though sharing a common ancestor with Archaea, was bounded by two membranes. The hypothesis suggests that an alpha proteic-bacterial symbiont was enclosed in the prokaryotic cells intermembrane space. In this view, the eukaryotic nuclear membrane and endomembrane system arose from the prokaryotic cells inner membrane while the eukaryotic plasma membrane arose from the prokaryotic cells outer membrane. The outlined scenario agrees with the view that engulfment of an alpha-proteic-bacterial cell by a host entity and its transformation to a mitochondrion was the driving force leading to the appearance of the first eukaryotic cell. The hypothesis seems to be consistent with the pre-cell theory, theory of membrane heredity, and the phagocytosis-late scenario.
提出了一种关于真核细胞起源的新假说。假定普遍共同祖先由具有异手性脂质组成的两层膜所界定。我们提出，原核细胞（α-变形菌的假定宿主实体）虽然与古菌有共同祖先，但由两层膜所界定。该假说表明，一个α-变形菌共生体被包裹在原核细胞的膜间空间。按照这种观点，真核细胞核膜和内膜系统起源于原核细胞的内膜，而真核细胞质膜起源于原核细胞的外膜。所概述的情形与这样一种观点一致，即宿主实体吞噬一个α-变形菌细胞并将其转化为线粒体是导致第一个真核细胞出现的驱动力。该假说似乎与前细胞理论、膜遗传理论以及吞噬作用晚期情形相一致。
