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[电刺激大鼠古小脑皮质对戊四氮点燃早期诱发的棘波-慢波活动的影响]

[The influence of electrical stimulation of the paleocerebellar cortex upon spike-wave activity induced at the early stage of corazol-induced kindling in rats].

作者信息

Kobolev E V

出版信息

Patol Fiziol Eksp Ter. 2006 Oct-Dec(4):23-5.

Abstract

Chronic Wistar rats experiments have shown that repeated administrations of corazol in subthreshold dosages (30.0 mg/kg, i.p.) were followed by spike-wave (SW) bursts of discharges. Duration of such bursts as well as common period of their registration were longer in the course of epileptogen administration. High-frequency (100 Hz0 electric stimulation of the paleocerebellar cortex decreased duration of SW-complexes and period of their registration while low-frequency (10 Hz) electric stimulation resulted in a short-term effect of reduction of duration of SW bursts.

摘要

对慢性Wistar大鼠的实验表明,以阈下剂量(30.0毫克/千克,腹腔注射)反复给予可拉佐后,会出现棘波(SW)放电爆发。在给予致痫剂的过程中,此类爆发的持续时间及其记录的总时长均更长。对古小脑皮质进行高频(100赫兹)电刺激可缩短SW复合波的持续时间及其记录时长,而低频(10赫兹)电刺激则会产生使SW爆发持续时间缩短的短期效应。

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