Makul'kin R F, Novitskiĭ S A
Fiziol Zh (1978). 1990 Jan-Feb;36(1):3-8.
Chronic experiments on the rats have shown that the pharmacological destruction of caudate nuclei significantly elevates the general brain excitation and induces rapid development of the corazol kindling. The hippocampal destruction exerts an opposite effect. Regression analysis of this processes has shown that mechanism of the general brain excitation and those of epileptogenesis are different on the stage of the developing kindling. Caudate nucleus activation induces powerful inhibition of kindling behavioral convulsive reactions and its electrographic epileptic activity. These data suggest that the caudate nucleus is a significant structure of the antiepileptic brain system and confirm G. N. Kryzhanovsky's concept about the system-antisystem interrelationship in case of neuropathologic syndromes as a result of the system hyperactivity.
对大鼠的慢性实验表明，尾状核的药理损伤会显著提高大脑的整体兴奋性，并诱导戊四氮点燃的快速发展。海马体损伤则产生相反的效果。对这些过程的回归分析表明，在点燃发展阶段，大脑整体兴奋机制和癫痫发生机制是不同的。尾状核激活会强烈抑制点燃的行为惊厥反应及其脑电图癫痫活动。这些数据表明，尾状核是抗癫痫脑系统的一个重要结构，并证实了G.N.克里扎诺夫斯基关于在神经病理综合征因系统活动亢进导致系统 - 反系统相互关系的概念。
