Phillips P E
Rheumatology. 1975;6:353-60.
Comparison of virus antibody titers in JRA and matched controls failed to implicate rubella, measles, parainfluenza type 1 or Epstein-Barr viruses. Neither RNA viruses or mycoplasma were detected in rheumatoid synovial cell cultures by 3H-uridine incorporation. Mycoplasma were not isolated from rheumatoid synovial membranes or cell cultures using the large specimen-broth culture procedure. The balance of available evidence, including our own, suggests that mycoplasma are not involved in RA. Viruses, however, are better candidates, in spite of similar generally negative studies to date, because methods for detecting known latent infection in animals and in vitro are still in their infancy. Those that are known have not yet been comprehensively applied to RA. Thus, supported by indirect evidence from animal models and human diseases like polyarteritis, the hypothesis that viruses are involved in the pathogenesis of RA remains attractive, although direct evidence is still lacking.
对青少年类风湿性关节炎（JRA）患者及配对对照者的病毒抗体滴度进行比较，结果未显示风疹、麻疹、1型副流感病毒或EB病毒与该病有关。通过3H-尿苷掺入法，在类风湿性滑膜细胞培养物中未检测到RNA病毒或支原体。采用大样本肉汤培养法，未从类风湿性滑膜组织或细胞培养物中分离出支原体。包括我们自己的研究在内，现有证据表明支原体与类风湿性关节炎无关。然而，病毒更有可能是病因，尽管目前的研究大多同样呈阴性结果，但因为检测动物体内及体外已知潜伏感染的方法仍处于起步阶段，且尚未全面应用于类风湿性关节炎的研究。目前已知的检测方法尚未在类风湿性关节炎研究中得到全面应用。因此，尽管仍缺乏直接证据，但在动物模型及诸如结节性多动脉炎等人类疾病的间接证据支持下，病毒参与类风湿性关节炎发病机制的假说仍然很有吸引力。
