大麻素在嗅觉上皮中的作用。
Cannabinoid action in the olfactory epithelium.
作者信息
Czesnik Dirk, Schild Detlev, Kuduz Josko, Manzini Ivan
机构信息
Department of Neurophysiology and Cellular Biophysics and Deutsche Forschungsgemeinschaft Research Center for Molecular Physiology of the Brain, University of Göttingen, Humboldtallee 23, 37073 Göttingen, Germany.
出版信息
Proc Natl Acad Sci U S A. 2007 Feb 20;104(8):2967-72. doi: 10.1073/pnas.0609067104. Epub 2007 Feb 14.
Abstract
The perception of odors is influenced by a variety of neuromodulators, and there is growing evidence that modulation already takes place in the olfactory epithelium. Here we report on cannabinergic actions in the olfactory epithelium of Xenopus laevis tadpoles. First we show that CB1 receptor-specific antagonists AM251, AM281, and LY320135 modulate odor-evoked calcium changes in olfactory receptor neurons. Second, we localize CB1-like immunoreactivity on dendrites of olfactory receptor neurons. Finally, we describe the cannabinergic influence on odor-induced spike-associated currents in individual olfactory receptor neurons. Here we demonstrate that the cannabinergic system has a profound impact on peripheral odor processing and discuss its possible function.
摘要
气味的感知受到多种神经调质的影响，并且越来越多的证据表明这种调节作用在嗅觉上皮中就已经发生。在此，我们报告非洲爪蟾蝌蚪嗅觉上皮中的大麻素能作用。首先，我们表明CB1受体特异性拮抗剂AM251、AM281和LY320135可调节嗅觉受体神经元中气味诱发的钙变化。其次，我们将CB1样免疫反应性定位在嗅觉受体神经元的树突上。最后，我们描述了大麻素能对单个嗅觉受体神经元中气味诱导的锋电位相关电流的影响。在此，我们证明大麻素能系统对周围气味处理有深远影响，并讨论其可能的功能。
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