Farid Reza, Azad Farahzad Jabbari, Atri Ahmad Ebrahimi, Rahimi Mahmoud Baradaran, Khaledan Asghar, Talaei-Khoei Mojtaba, Ghafari Javad, Ghasemi Ramin
Department of Immunology and Allergy, Ghaem Medical Center, Mashhad University of Medical Sciences, Mashhad, Iran.
Iran J Allergy Asthma Immunol. 2005 Sep;4(3):133-8.
The aim of the present study was to examine the effects of a course of aerobic exercise on pulmonary function and tolerance of activity in asthmatic patients. Among the asthmatic patients, 36 patients (M= 16, F= 20) were chosen after clinical examinations, pulmonary function test, skin prick test (SPT) for aeroallergen and a six minute walk test (6MWT) on their own free will. A patient was said to have Exercise Induced Asthma (EIA) when he/she fulfilled the following criteria; (1) FEV1 less than 80%, (2) 12% increase or more in FEV1 or PEF after short-acting ss2 agonist prescription and (3) 15% decrease in FEV1 or PEF after 6MWT with 70% or 80% of maximum heart rate. The patients were randomly put into two groups of case (M=8, F=10, Mean age=27) and control (M=8, F=10, Mean age=29). Case group participated in eight-week aerobic exercise plan, while control group had no plan of exercise. Pulmonary function tests were done before and after the course of exercise. There were significant changes in FEV1, FVC, PEF, FEF25-75%, MVV, RF and 6MWT between asthmatic patients of the two groups (P less than or equal to 0.05), but FEV1/FVC showed no significant change. Mean of changes in FEV1, FVC, PEF, FEF25-75%, MVV, RF and 6MWT were -25.56, -17.19, 32.09, -27.93, -22.18, 5.63 and -307.5 in case group respectively while they were 6.2, 4.67, 1.96, 6.65, 15.56,-2.87 and 18.78 in the control group. This study shows that aerobic exercises in asthmatic patients lead to an improvement in pulmonary functions. Aerobic exercise rehabilitation can be a complement to medical treatment of asthma.
本研究的目的是探讨有氧运动疗程对哮喘患者肺功能和活动耐量的影响。在哮喘患者中,36例患者(男16例,女20例)经临床检查、肺功能测试、气传变应原皮肤点刺试验(SPT)和六分钟步行试验(6MWT)后自愿入选。当患者符合以下标准时,即被诊断为运动诱发性哮喘(EIA):(1)第一秒用力呼气容积(FEV1)低于80%;(2)吸入短效β2激动剂后FEV1或呼气峰流速(PEF)增加12%或更多;(3)6MWT后,当心率达到最大心率的70%或80%时,FEV1或PEF下降15%。患者被随机分为病例组(男8例,女10例,平均年龄27岁)和对照组(男8例,女10例,平均年龄29岁)。病例组参加为期八周的有氧运动计划,而对照组没有运动计划。在运动疗程前后进行肺功能测试。两组哮喘患者的FEV1、用力肺活量(FVC)、PEF、25%-75%用力呼气流量(FEF25-75%)、最大通气量(MVV)、残气量(RV)和6MWT有显著变化(P≤0.05),但FEV1/FVC无显著变化。病例组FEV1、FVC、PEF、FEF25-75%、MVV、RV和6MWT的变化均值分别为-25.56、-17.19、32.09、-27.93、-22.18、5.63和-307.5,而对照组分别为6.2、4.67、1.96、6.65、15.56、-2.87和18.78。本研究表明,哮喘患者进行有氧运动可改善肺功能。有氧运动康复可作为哮喘药物治疗的补充。