Lal Simon, Steinhart A Hillary
Department of Gastroenterology, University Hospitals, Aintree, Liverpool, UK.
Eur J Gastroenterol Hepatol. 2007 Mar;19(3):277-80. doi: 10.1097/MEG.0b013e3280116ccc.
Primary sclerosing cholangitis is a chronic cholestatic disease with a progressive course, often culminating in hepatic transplantation. When associated with primary sclerosing cholangitis, ulcerative colitis commonly follows a mild course before, but a more progressive course following liver transplantation, with a significant proportion of patients becoming steroid dependent and/or requiring colectomy. We report the first case demonstrating the efficacy and safety of infliximab therapy for ulcerative colitis following hepatic transplantation.
原发性硬化性胆管炎是一种病程呈进行性发展的慢性胆汁淤积性疾病，常最终需要进行肝移植。当与原发性硬化性胆管炎相关时，溃疡性结肠炎在肝移植前通常病程较轻，但在肝移植后病程更为进展，相当一部分患者会出现激素依赖和/或需要行结肠切除术。我们报告首例证明英夫利昔单抗治疗肝移植后溃疡性结肠炎有效性和安全性的病例。
