Shader R I, Greenblatt D J
Am J Psychiatry. 1977 Jun;134(6):652-6. doi: 10.1176/ajp.134.6.652.
Pharmacokinetic research has shown that clear differences exist among benzodiazepines in rate and route of elimination and in the presence or absence of pharmacologically active metabolites. These findings and other results of pharmacokinetic research have clinical implications in terms of dosage schedules, drug accumulation during long-term therapy, antianxiety therapy in the elderly, drug interactions, pharmacotherapy in specific disease states, and the influence of route of administration on drug action.
药代动力学研究表明，苯二氮䓬类药物在消除速率和途径以及是否存在药理活性代谢物方面存在明显差异。这些研究结果以及药代动力学研究的其他结果在给药方案、长期治疗期间的药物蓄积、老年人的抗焦虑治疗、药物相互作用、特定疾病状态下的药物治疗以及给药途径对药物作用的影响等方面具有临床意义。
