神经症门诊患者的临床反应、心理生理变量与阿米替林和地西泮血浆水平之间的关系。

The relationships between clinical response, psychophysiological variables and plasma levels of amitriptyline and diazepam in neurotic outpatients.

作者信息

Johnstone E C, Bourne R C, Crow T J, Frith C D, Gamble S, Lofthouse R, Owen F, Owens D G, Robinson J, Stevens M

出版信息

Psychopharmacology (Berl). 1981;72(3):233-40. doi: 10.1007/BF00431822.

Abstract

In a 4 week study of the response of neurotic outpatients to treatment with amitriptyline, diazepam, amitriptyline and diazepam, or placebo clinical and psychophysiological variables and plasma levels of the drug were assessed. Clinical improvements were substantial in all treatment groups but clear relationships between clinical change, psychophysiological change and plasma levels of the drugs were not established. There was no relationship between plasma levels of the drugs and cigarette smoking. It is concluded that neither plasma levels of amitriptyline and diazepam nor change in skin conductance responsivity offer a useful guide to clinical response to drug treatment.

摘要

在一项针对神经症门诊患者使用阿米替林、地西泮、阿米替林与地西泮联合用药或安慰剂进行治疗的为期4周的研究中，对临床及心理生理变量以及药物的血浆水平进行了评估。所有治疗组均有显著的临床改善，但未确立临床变化、心理生理变化与药物血浆水平之间的明确关系。药物血浆水平与吸烟之间没有关系。得出的结论是，无论是阿米替林和地西泮的血浆水平，还是皮肤电导率反应性的变化，都不能为药物治疗的临床反应提供有用的指导。