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非裔美国人乳腺癌风险的遗传咨询与检测

Genetic counseling and testing for breast cancer risk in African Americans.

作者信息

Halbert Chanita Hughes

机构信息

Leonard Davis Institute of Health Economics (LDI), University of Pennsylvania, USA.

出版信息

LDI Issue Brief. 2006 Sep;12(1):1-4.

Abstract

Genetic testing for susceptibility to breast and ovarian cancer (BRCA1/2 testing) has been available in clinical settings since 1996. Increasingly, such testing is helping women at increased risk make decisions about breast cancer screening and prevention. African American women have participated in genetic counseling and testing programs less than white women, despite greater rates of early onset disease and higher breast cancer mortality. The barriers and motivations for genetic testing among African American women are not well understood. This Issue Brief summarizes a series of studies that systematically explore African American women's beliefs and intentions about BRCA1/2 testing. The findings have been used to tailor genetic counseling programs to better serve this population.

摘要

自1996年以来,乳腺癌和卵巢癌易感性基因检测(BRCA1/2检测)已在临床环境中开展。越来越多的此类检测正在帮助风险增加的女性做出关于乳腺癌筛查和预防的决策。尽管非裔美国女性早期发病几率更高且乳腺癌死亡率更高,但她们参与遗传咨询和检测项目的比例低于白人女性。非裔美国女性进行基因检测的障碍和动机尚未得到充分了解。本问题简报总结了一系列系统探索非裔美国女性对BRCA1/2检测的信念和意图的研究。这些研究结果已被用于调整遗传咨询项目,以更好地服务这一人群。

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