Hatano Kentaro
Department of Brain Sciences and Molecular Imaging, National Institute for Longevity Sciences, National Center for Geriatrics and Gerontology.
Nihon Rinsho. 2007 Feb;65(2):332-5.
Imaging of microglia cells using the radiolabeled ligand toward peripheral benzodiazepine receptor(PBR) is applied to brain injury and neurodegenerative diseases. A novel PBR radioligand other than [11C] PK11195 might be desirable to detailedly delineate this complicated phenomenon and a novel idea other than in vitro PBR binding ability is desirable to expect feasibility of a new candidate. Current status, problems and future prospects associated with indirect imaging of microglial activity with [11C] PK11195 will be discussed.
使用针对外周苯二氮䓬受体（PBR）的放射性标记配体对小胶质细胞进行成像，已应用于脑损伤和神经退行性疾病。除了[11C]PK11195之外，可能需要一种新型的PBR放射性配体来详细描述这一复杂现象，并且需要一种不同于体外PBR结合能力的新思路来评估新候选物的可行性。将讨论与使用[11C]PK11195对小胶质细胞活性进行间接成像相关的现状、问题和未来前景。
