Berglund S, Zettervall O
Department of Medicine, University of Lund, Malmö General Hospital, Sweden.
Eur J Haematol. 1992 Jan;48(1):20-6. doi: 10.1111/j.1600-0609.1992.tb01788.x.
In this retrospective investigation from Malmö, a city well-suited for epidemiologic studies, 177 patients (88 males and 89 females) with polycythemia vera (PV) were identified between 1950 and 1984. The incidence rate (number of cases/100,000/yr) in both sexes increased significantly, being 1.0 in 1950-1959 and 2.6 in 1980-1984 (adjusted to the European age-standardized population). This is the highest rate reported to date. In 1970-1984 the highest age-specific incidence rates (number of cases/100,000/yr) were found in males greater than or equal to 80 yr and females 70-79 yr of age, being 18.3 and 14.6, respectively. A subgroup of 12 (7%) was identified where the PV diagnosis was not obvious on entry into the study but where it became clear during follow-up. 16 PV patients (9%) had verified or suspected arterial hypoxemia caused by a concomitant condition. We conclude that the increasing PV incidence rates, mainly confined to older age groups, are probably due to better case ascertainment.
在马尔默市进行的这项回顾性调查中，马尔默是一个非常适合进行流行病学研究的城市，在1950年至1984年期间共识别出177例真性红细胞增多症（PV）患者（88例男性和89例女性）。两性的发病率（病例数/10万/年）均显著增加，1950 - 1959年为1.0，1980 - 1984年为2.6（根据欧洲年龄标准化人口进行调整）。这是迄今为止报告的最高发病率。1970 - 1984年，年龄特异性发病率最高（病例数/10万/年）的是80岁及以上男性和70 - 79岁女性，分别为18.3和14.6。有12例（7%）患者在进入研究时PV诊断不明显，但在随访期间明确诊断。16例PV患者（9%）因并发疾病导致动脉血氧不足得到证实或怀疑。我们得出结论，PV发病率的增加主要局限于老年人群体，可能是由于病例确诊率提高所致。
