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Candesartan cilexetil in children with hypertension or proteinuria: preliminary data.坎地沙坦酯用于患有高血压或蛋白尿的儿童：初步数据。
Pediatr Nephrol. 2006 Oct;21(10):1480-2. doi: 10.1007/s00467-006-0144-0. Epub 2006 Jun 27.
2
A pooled analysis of seven randomized crossover studies of the palatability of cefdinir oral suspension versus amoxicillin/clavulanate potassium, cefprozil, azithromycin, and amoxicillin in children aged 4 to 8 years.一项针对4至8岁儿童中头孢地尼口服混悬液与阿莫西林/克拉维酸钾、头孢丙烯、阿奇霉素及阿莫西林口感的七项随机交叉研究的汇总分析。
Clin Ther. 2005 Dec;27(12):1950-60. doi: 10.1016/j.clinthera.2005.11.017.
3
Formulation of medicines for children.儿童用药制剂
Br J Clin Pharmacol. 2005 Jun;59(6):674-6. doi: 10.1111/j.1365-2125.2005.02410.x.
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"Why do they do that?" The compliance conundrum.“他们为什么要那样做？”合规难题。
Pediatr Nephrol. 2005 Jul;20(7):845-8. doi: 10.1007/s00467-005-1926-5. Epub 2005 May 24.
5
A double-blind, dose-response study of losartan in hypertensive children.氯沙坦用于高血压儿童的双盲剂量反应研究。
Am J Hypertens. 2005 Feb;18(2 Pt 1):183-90. doi: 10.1016/j.amjhyper.2004.09.009.
6
Antihypertensive and renoprotective efficacy and safety of losartan. A long-term study in children with renal disorders.氯沙坦的降压及肾脏保护疗效与安全性：一项针对患有肾脏疾病儿童的长期研究
Am J Hypertens. 2004 Oct;17(10):928-35. doi: 10.1016/j.amjhyper.2004.06.014.
7
Better renoprotective effect of angiotensin II antagonist compared to dihydropyridine calcium channel blocker in childhood.在儿童期，血管紧张素II拮抗剂比二氢吡啶类钙通道阻滞剂具有更好的肾脏保护作用。
Kidney Int. 2003 Oct;64(4):1450-4. doi: 10.1046/j.1523-1755.2003.00238.x.
8
Long-term antiproteinuric and renoprotective efficacy and safety of losartan in children with proteinuria.氯沙坦对儿童蛋白尿的长期抗蛋白尿及肾脏保护疗效与安全性
J Pediatr. 2003 Jul;143(1):89-97. doi: 10.1016/S0022-3476(03)00279-8.
9
Effectiveness and safety of the angiotensin II antagonist irbesartan in children with chronic kidney diseases.血管紧张素II拮抗剂厄贝沙坦在慢性肾脏病儿童中的有效性和安全性。
Am J Hypertens. 2002 Dec;15(12):1057-63. doi: 10.1016/s0895-7061(02)03083-2.
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The pharmacokinetics of irbesartan in hypertensive children and adolescents.
J Clin Pharmacol. 2001 Jul;41(7):742-9. doi: 10.1177/00912700122010645.

血管紧张素II拮抗剂在肾病患儿中的适口性。

Palatability of angiotensin II antagonists among nephropathic children.

作者信息

Meier Chiara M, Simonetti Giacomo D, Ghiglia Silvia, Fossali Emilio, Salice Patrizia, Limoni Costanzo, Bianchetti Mario G

机构信息

Ospedale San Giovanni Bellinzona and Ospedale della Beata Vergine, Mendrisio, Switzerland.

出版信息

Br J Clin Pharmacol. 2007 May;63(5):628-31. doi: 10.1111/j.1365-2125.2006.02814.x. Epub 2007 Feb 14.

DOI:10.1111/j.1365-2125.2006.02814.x
PMID:17302913
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC2000746/
Abstract

WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT

  • Among children, medication palatability is crucial for adherence to therapeutic regimen. * Several studies have measured the palatability of antimicrobial suspensions in paediatric patients by means of a visual analogue scale palatability score.

WHAT THIS STUDY ADDS

  • This is the first analysis comparing the taste and smell acceptability of angiotensin II receptor blockers among paediatric patients with kidney disease. * From the perspective of the child with kidney disease, the taste of pulverized candesartan is significantly superior to that of pulverized irbesartan, losartan, telmisartan or valsartan.

AIM

Angiotensin II receptor blockers are widely prescribed in kidney disease. Among children, medication palatability is crucial for adherence.

METHODS

Taste and smell acceptability of five angiotensin II receptor blockers were compared among 21 nephropathic children using a visual analogue scale palatability score.

RESULTS

The score assigned to pulverized tablets of candesartan cilexetil was significantly higher than that assigned to pulverized tablets of irbesartan, losartan, telmisartan and valsartan.

CONCLUSIONS

From the perspective of the nephropathic child, the taste of pulverized candesartan cilexetil is superior to that of irbesartan, losartan, telmisartan or valsartan.

摘要

关于该主题的已知信息

  • 在儿童中，药物的适口性对于坚持治疗方案至关重要。

  • 多项研究通过视觉模拟量表适口性评分来衡量儿科患者抗菌药物混悬液的适口性。

本研究的新增内容

  • 这是首次比较肾病儿科患者中血管紧张素II受体阻滞剂的味道和气味可接受性的分析。

  • 从肾病患儿的角度来看，坎地沙坦碾碎后的味道明显优于厄贝沙坦、氯沙坦、替米沙坦或缬沙坦碾碎后的味道。

目的

血管紧张素II受体阻滞剂在肾病治疗中广泛应用。在儿童中，药物适口性对于坚持治疗至关重要。

方法

使用视觉模拟量表适口性评分，比较21名肾病儿童对五种血管紧张素II受体阻滞剂的味道和气味可接受性。

结果

坎地沙坦酯片碾碎后的评分显著高于厄贝沙坦、氯沙坦、替米沙坦和缬沙坦碾碎后的评分。

结论

从肾病患儿的角度来看，坎地沙坦酯片碾碎后的味道优于厄贝沙坦、氯沙坦、替米沙坦或缬沙坦。