血管紧张素II拮抗剂在肾病患儿中的适口性。
Palatability of angiotensin II antagonists among nephropathic children.
作者信息
Meier Chiara M, Simonetti Giacomo D, Ghiglia Silvia, Fossali Emilio, Salice Patrizia, Limoni Costanzo, Bianchetti Mario G
机构信息
Ospedale San Giovanni Bellinzona and Ospedale della Beata Vergine, Mendrisio, Switzerland.
出版信息
Br J Clin Pharmacol. 2007 May;63(5):628-31. doi: 10.1111/j.1365-2125.2006.02814.x. Epub 2007 Feb 14.
Abstract
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT
- Among children, medication palatability is crucial for adherence to therapeutic regimen. * Several studies have measured the palatability of antimicrobial suspensions in paediatric patients by means of a visual analogue scale palatability score.
WHAT THIS STUDY ADDS
- This is the first analysis comparing the taste and smell acceptability of angiotensin II receptor blockers among paediatric patients with kidney disease. * From the perspective of the child with kidney disease, the taste of pulverized candesartan is significantly superior to that of pulverized irbesartan, losartan, telmisartan or valsartan.
AIM
Angiotensin II receptor blockers are widely prescribed in kidney disease. Among children, medication palatability is crucial for adherence.
METHODS
Taste and smell acceptability of five angiotensin II receptor blockers were compared among 21 nephropathic children using a visual analogue scale palatability score.
RESULTS
The score assigned to pulverized tablets of candesartan cilexetil was significantly higher than that assigned to pulverized tablets of irbesartan, losartan, telmisartan and valsartan.
CONCLUSIONS
From the perspective of the nephropathic child, the taste of pulverized candesartan cilexetil is superior to that of irbesartan, losartan, telmisartan or valsartan.
摘要
关于该主题的已知信息
在儿童中，药物的适口性对于坚持治疗方案至关重要。
多项研究通过视觉模拟量表适口性评分来衡量儿科患者抗菌药物混悬液的适口性。
本研究的新增内容
这是首次比较肾病儿科患者中血管紧张素II受体阻滞剂的味道和气味可接受性的分析。
从肾病患儿的角度来看，坎地沙坦碾碎后的味道明显优于厄贝沙坦、氯沙坦、替米沙坦或缬沙坦碾碎后的味道。
目的
血管紧张素II受体阻滞剂在肾病治疗中广泛应用。在儿童中，药物适口性对于坚持治疗至关重要。
方法
使用视觉模拟量表适口性评分，比较21名肾病儿童对五种血管紧张素II受体阻滞剂的味道和气味可接受性。
结果
坎地沙坦酯片碾碎后的评分显著高于厄贝沙坦、氯沙坦、替米沙坦和缬沙坦碾碎后的评分。
结论
从肾病患儿的角度来看，坎地沙坦酯片碾碎后的味道优于厄贝沙坦、氯沙坦、替米沙坦或缬沙坦。
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