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超声检查对抵抗性卵巢综合征的无创诊断

Noninvasive diagnosis of resistant ovary syndrome by ultrasonography.

作者信息

Mehta A E, Matwijiw I, Lyons E A, Faiman C

机构信息

University of Manitoba, Winnipeg, Canada.

出版信息

Fertil Steril. 1992 Jan;57(1):56-61.

PMID:1730331
Abstract

OBJECTIVE

To compare transvaginal ultrasonographic features of the ovaries and endometrium of patients with premature ovarian failure to normally cycling women on oral contraceptives (OCs), menopausal women with an equivalent duration of amenorrhea to the premature ovarian failure group, and patients with Turner's syndrome.

DESIGN

Transvaginal ultrasonography in groups of women with premature ovarian failure, OC, and menopause.

SETTING

All subjects were studied in an academic tertiary care center.

PATIENTS/PARTICIPANTS: Seventeen women with premature ovarian failure, 20 volunteers on OC, 20 with menopause, and 4 patients with Turner's syndrome were studied.

INTERVENTION

None, except for OCs in the OC group only.

MAIN OUTCOME MEASURES

Frequency of ovarian, ovarian follicle, and endometrial visualization and their respective measurement in the three groups.

RESULTS

At least one ovary was visualized in 84% of the premature ovarian failure patients as compared with 95% of the OC and menopause groups and 25% of the Turner patients. Mean ovarian volume was smaller in the premature ovarian failure group as compared with the OC group but equal to that of the menopause group. In the premature ovarian failure group, 41% had follicles in their ovaries as compared with 95% in the OC group, 5% in the menopause group, and none in the Turner group. The number of follicles per ovary was significantly lower in the premature ovarian failure as compared with the OC group, whereas only one subject had a single follicle in the menopause group. Premature ovarian failure subjects with follicles had larger ovaries than those without follicles. Endometrial thickness was not different among the groups.

CONCLUSION

Ultrasonography may serve to identify a substantial subset (approximately 40%) of premature ovarian failure patients with ovarian follicles and potential for fertility consistent with the diagnosis of resistant ovary syndrome.

摘要

目的

比较卵巢早衰患者与口服避孕药(OC)的正常月经周期女性、闭经时间与卵巢早衰组相当的绝经后女性以及特纳综合征患者的卵巢和子宫内膜的经阴道超声特征。

设计

对卵巢早衰组、OC组和绝经组女性进行经阴道超声检查。

地点

所有受试者均在一家学术性三级医疗中心进行研究。

患者/参与者:研究了17例卵巢早衰女性、20名服用OC的志愿者、20例绝经后女性和4例特纳综合征患者。

干预措施

除OC组仅服用OC外,无其他干预措施。

主要观察指标

三组中卵巢、卵泡及子宫内膜的可视化频率及其各自的测量值。

结果

84%的卵巢早衰患者至少有一侧卵巢可被观察到,而OC组和绝经组的这一比例为95% , 特纳综合征患者为25%。卵巢早衰组的平均卵巢体积小于OC组,但与绝经组相等。在卵巢早衰组中,41%的患者卵巢中有卵泡,而OC组为95%,绝经组为5%,特纳组则无卵泡。与OC组相比,卵巢早衰组每个卵巢的卵泡数量显著减少,而绝经组只有1名受试者有单个卵泡。有卵泡的卵巢早衰受试者的卵巢比无卵泡者更大。各组间子宫内膜厚度无差异。

结论

超声检查可用于识别相当一部分(约40%)卵巢早衰患者,这些患者有卵巢卵泡且具有与抵抗性卵巢综合征诊断相符的生育潜力。

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