Wachter Rolf, Lüers Claus, Kleta Sibylle, Griebel Kerstin, Herrmann-Lingen Christoph, Binder Lutz, Janicke Nico, Wetzel Dirk, Kochen Michael M, Pieske Burkert
Department of Cardiology and Pneumology, University of Göttingen, Robert-Koch-Str. 40, 37075 Göttingen, Germany.
Eur J Heart Fail. 2007 May;9(5):469-76. doi: 10.1016/j.ejheart.2007.01.001. Epub 2007 Feb 15.
To analyse the effect of diabetes (DM) on diastolic function in hypertensive patients.
439 hypertensive patients were selected for participation in this study. All participants had an echocardiographic evaluation of systolic and diastolic function. The overall degree of diastolic function and specific parameters (e.g. E/Ea ratio) were analysed.
We divided the cohort (63+/-10 years) into those with diabetes mellitus (DM(+), n=124) and without diabetes mellitus (DM(-), n=315). The prevalence of normal diastolic function was lower in DM(+) than DM(-) (19.4% vs. 30.8%); mild (65.3% vs. 60.0%) and moderate/ severe diastolic dysfunction were more frequent in DM(+) (15.3% vs. 9.2%, p=0.022). The E/Ea ratio, an estimate of left ventricular end-diastolic pressure, was significantly higher in DM(+) (12.3+/-4.4) as compared to DM(-) (10.8+/-3.6, p<0.001). Sex-specific analysis revealed that the effect of DM on diastolic function was mainly limited to the male subgroup. Multivariate logistic regression analysis showed that diabetes affected diastolic function in males independent of blood pressure, left ventricular mass index, concomitant medication and prevalence of coronary artery disease.
Diabetes negatively affects diastolic function in patients with arterial hypertension. This effect is mainly confined to the male subgroup.
分析糖尿病（DM）对高血压患者舒张功能的影响。
选取439例高血压患者参与本研究。所有参与者均接受了收缩和舒张功能的超声心动图评估。分析舒张功能的总体程度和特定参数（如E/Ea比值）。
我们将该队列（63±10岁）分为糖尿病患者（DM(+)，n = 124）和非糖尿病患者（DM(-)，n = 315）。DM(+)组舒张功能正常的患病率低于DM(-)组（19.4%对30.8%）；DM(+)组轻度（65.3%对60.0%）和中度/重度舒张功能障碍更为常见（15.3%对9.2%，p = 0.022）。作为左心室舒张末期压力估计值的E/Ea比值，DM(+)组（12.3±4.4）显著高于DM(-)组（10.8±3.6，p < 0.001）。按性别进行的分析显示，DM对舒张功能的影响主要限于男性亚组。多因素逻辑回归分析表明，糖尿病独立于血压、左心室质量指数、合并用药和冠状动脉疾病患病率影响男性的舒张功能。
糖尿病对动脉高血压患者的舒张功能有负面影响。这种影响主要局限于男性亚组。
