Likes Wendy M, Stegbauer Cheryl, Tillmanns Todd, Pruett James
University of Tennessee Health Science Center, College of Nursing, Memphis, TN 38103, USA.
Gynecol Oncol. 2007 Jun;105(3):600-3. doi: 10.1016/j.ygyno.2007.01.027. Epub 2007 Feb 15.
The objectives were to evaluate associations between size of excision, grade of VIN, demographic variables, location of excision and laterality and sexual function and quality of life (QOL) in women with vulvar intraepithelial neoplasia (VIN) following vulvar excision.
Forty-three women with VIN who had undergone a vulvar excision completed the Female Sexual Function Index (FSFI) and the European Organization for Research and Treatment of Cancer QLQ-C30 (QLQ C-30) scale to provide an assessment of sexual function and QOL. Medical records of the participants were reviewed for pathology results, operative reports, and medication history. Correlation and multiple regression analyses were performed to determine associations between collected variables and sexual function and QOL scores.
Most participants (n=43) were Caucasian (76.6%) and smoked (69.8%). Age significantly correlated with FSFI total score (Pearson r=-.470, p=.001), along with size of excision (r=-.412, p=.009). Neither VIN grade, location of excision, nor time since excision correlated with sexual function or QOL.
Older age and a more extensive vulvar excision were associated with poorer sexual function and QOL in women following surgical treatment for VIN. Further study with a larger sample and additional variables is needed to better understand the effect of vulvar excision on women's sexual function and QOL.
本研究旨在评估外阴上皮内瘤变（VIN）患者外阴切除术后，切除范围、VIN分级、人口统计学变量、切除部位及双侧性与性功能和生活质量（QOL）之间的相关性。
43例接受外阴切除术的VIN患者完成了女性性功能指数（FSFI）和欧洲癌症研究与治疗组织生活质量核心问卷（QLQ-C30）量表评估，以了解其性功能和生活质量。查阅参与者的病历，获取病理结果、手术报告和用药史。进行相关性和多元回归分析，以确定所收集变量与性功能及生活质量评分之间的关联。
大多数参与者（n = 43）为白种人（76.6%）且有吸烟史（69.8%）。年龄与FSFI总分显著相关（Pearson r = -0.470，p = 0.001），切除范围也与之相关（r = -0.412，p = 0.009）。VIN分级、切除部位及术后时间均与性功能或生活质量无关。
年龄较大及外阴切除范围较大与VIN手术治疗后女性的性功能及生活质量较差有关。需要进一步开展更大样本量及纳入更多变量的研究，以更好地了解外阴切除术对女性性功能和生活质量的影响。
