Battikh R, M'sadek F, Ben Abdelhafidh N, Louzir B, Labidi J, Ajili F, Jemli B, Gargouri S, Cheikh R, Othmani S
Service de médecine interne, hôpital militaire de Tunis, Tunisia.
Med Mal Infect. 2007 Sep;37(9):605-8. doi: 10.1016/j.medmal.2006.03.005. Epub 2007 Feb 15.
We report 3 cases of pneumocystis pneumonia (PCP) in 2 female and 1 male patients (mean age=50 years) free of human immunodeficiency virus (HIV) infection. One female patient presented with breast neoplasm the other with Wegener's granulomatosis, the male patient with lymphoma. All patients were taking immunosuppressive treatment at the time of infection. Persistent cough, dyspnea, and severe hypoxemia were the most characteristic clinical signs. All patients presented with lymphopenia (average CD4-cell count=275/mm3), two with hypoalbuminemia, and one with renal failure. In all cases, the microscopic analysis of bronchoalveolar lavage was used to establish the diagnosis. All patients were treated with trimethoprim and sulfamethoxazole and a tapering dose of corticosteroids. Outcome was favorable for 1 patient, 1 was transferred to the intensive care unit for acute respiratory failure, and 1 died.
我们报告了3例肺孢子菌肺炎（PCP）病例，患者为2名女性和1名男性（平均年龄50岁），均无人类免疫缺陷病毒（HIV）感染。1名女性患者患有乳腺肿瘤，另1名患有韦格纳肉芽肿，男性患者患有淋巴瘤。所有患者在感染时均接受免疫抑制治疗。持续性咳嗽、呼吸困难和严重低氧血症是最典型的临床症状。所有患者均出现淋巴细胞减少（平均CD4细胞计数=275/mm³），2例伴有低白蛋白血症，1例伴有肾衰竭。所有病例均通过支气管肺泡灌洗的显微镜分析来确诊。所有患者均接受了甲氧苄啶和磺胺甲恶唑治疗以及逐渐减量的皮质类固醇治疗。1例患者预后良好，1例因急性呼吸衰竭转入重症监护病房，1例死亡。
