[Noncoenzymic function of vitamin PP].

The article deals with the experimental data of the authors and those from literature on interrelation between NAD and DNA metabolism in hepatocytes and the role of nuclear NAD-glycohydrolase and NAD-pyrophosphorylase in these processes. Considerable attention is paid to the information on biosynthesis, structure and biochemical functions of poly(ADPR)--a new polymer formed in eucariots nuclei from NAD. The data on the effects of vitamin PP and its biologically active derivative--NAD on DNA synthesis, proliferation of cells and on their genic activity are presented and discussed from modern view points on noncoenzymatic functions of this vitamin.