Sims J L, Berger S J, Berger N A
J Supramol Struct Cell Biochem. 1981;16(3):281-8. doi: 10.1002/jsscb.1981.380160308.
The effect of nicotinamide on unscheduled DNA synthesis was studied in resting human lymphocytes. In cells treated with UV irradiation or with MNNG, nicotinamide caused a two-fold stimulation of unscheduled DNA synthesis and retarded the rate of NAD+ lowering caused by these treatments. Nicotinamide also reduced the burst of poly(ADP-ribose) synthesis caused by MNNG treatment. Thus under conditions that it enhances unscheduled DNA synthesis, nicotinamide causes marked effects on the metabolism of NAD+ and poly(ADP-ribose). The effect of nicotinamide on unscheduled DNA synthesis was shown to be independent of protein or polyamine synthesis.
在静止的人淋巴细胞中研究了烟酰胺对非定标性DNA合成的影响。在用紫外线照射或N-甲基-N'-硝基-N-亚硝基胍（MNNG）处理的细胞中，烟酰胺使非定标性DNA合成受到两倍的刺激，并减缓了这些处理所导致的NAD⁺降低速率。烟酰胺还减少了MNNG处理所引起的聚（ADP-核糖）合成的爆发。因此，在增强非定标性DNA合成的条件下，烟酰胺对NAD⁺和聚（ADP-核糖）的代谢产生显著影响。结果表明，烟酰胺对非定标性DNA合成的影响与蛋白质或多胺合成无关。
