Mårtensson Inga-Lill, Keenan Rebecca A, Licence Steve
Laboratory of Lymphocyte Signaling and Development, The Babraham Institute, The Babraham Campus, Cambridge CB2 4AT, United Kingdom.
Curr Opin Immunol. 2007 Apr;19(2):137-42. doi: 10.1016/j.coi.2007.02.006. Epub 2007 Feb 15.
The pre-B-cell receptor (pre-BCR) is composed of two immunoglobulin mu heavy chains and two surrogate light chains, which associate with the signaling molecules Igalpha and Igbeta (Igalpha/beta). The production of a functional pre-BCR is the first checkpoint in the current model of B-cell development. The pre-BCR mediates signals resulting in heavy chain allelic exclusion, down-regulation of the recombination machinery, developmental progression, V(H) repertoire selection, proliferation and down-regulation of the surrogate light chain genes. Recent studies suggest that some of these processes could take place at an earlier stage in B-cell development than previously thought, and might not result from signals mediated by the pre-BCR.
前B细胞受体（pre-BCR）由两条免疫球蛋白μ重链和两条替代轻链组成，它们与信号分子Igalpha和Igbeta（Igalpha/beta）相关联。功能性pre-BCR的产生是当前B细胞发育模型中的第一个检查点。pre-BCR介导的信号导致重链等位基因排斥、重组机制的下调、发育进程、V(H)库选择、增殖以及替代轻链基因的下调。最近的研究表明，其中一些过程可能在B细胞发育的比之前认为的更早阶段发生，并且可能不是由pre-BCR介导的信号导致的。
