萎缩糜烂型和网状口腔扁平苔藓患者局部血管生成及血管内皮生长因子的评估
Assessment of local angiogenesis and vascular endothelial growth factor in the patients with atrophic-erosive and reticular oral lichen planus.
作者信息
Tao Xiaoan, Huang Yulei, Li Ruyao, Qing Ronghui, Ma Li, Rhodus Nelson L, Cheng Bin
机构信息
Department of Oral Medicine, Guanghua School of Stomatology, Sun Yat-sen University, Guangzhou, Guangdong, PR China.
出版信息
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2007 May;103(5):661-9. doi: 10.1016/j.tripleo.2006.05.023. Epub 2006 Oct 16.
OBJECTIVES
The objective of this study was to assess local angiogenesis and expression of VEGF in atrophic-erosive and reticular oral lichen planus (OLP).
STUDY DESIGN
Microvessel density (MVD) and VEGF level in 30 OLP subjects and 7 matched controls were detected by immunohistochemistry and ELISA.
RESULTS
MVD and VEGF levels in whole OLP group were significantly elevated (P = .033, P < .0001, respectively), and there was a positive correlation between MVD and VEGF (correlation coefficient = 0.84, P < .0001). MVD in atrophic-erosive OLP was significantly higher than that in controls (P = .001) and reticular OLP (P = .042), and the expression of VEGF in both subgroups was significantly higher (P < .0001, P = .008, respectively) compared to control group.
CONCLUSION
These results indicated that angiogenesis and VEGF expression were closely correlated to the different clinical forms of OLP lesions, which may give new insights into the mechanisms and treatment strategy of OLP.
目的
本研究的目的是评估萎缩糜烂型和网状型口腔扁平苔藓（OLP）中的局部血管生成及血管内皮生长因子（VEGF）的表达。
研究设计
采用免疫组织化学和酶联免疫吸附测定法（ELISA）检测30例OLP患者及7例匹配对照的微血管密度（MVD）和VEGF水平。
结果
整个OLP组的MVD和VEGF水平显著升高（分别为P = 0.033，P < 0.0001），且MVD与VEGF之间存在正相关（相关系数 = 0.84，P < 0.0001）。萎缩糜烂型OLP的MVD显著高于对照组（P = 0.001）和网状型OLP（P = 0.042），与对照组相比，两个亚组中VEGF的表达均显著更高（分别为P < 0.0001，P = 0.008）。
结论
这些结果表明血管生成和VEGF表达与OLP病变的不同临床类型密切相关，这可能为OLP的发病机制和治疗策略提供新的见解。
Zotero 插件