Krithika S, Trivedi R, Kashyap V K, Vasulu T S
Biological Anthropology Unit, Indian Statistical Institute, Kolkata 700 108, West Bengal, India.
Leg Med (Tokyo). 2007 Jul;9(4):210-7. doi: 10.1016/j.legalmed.2007.01.002. Epub 2007 Feb 15.
Fifteen autosomal STR loci were analyzed in 223 healthy individuals belonging to three remote, isolated Tibeto-Burman speaking sub tribes namely, Panggi, Komkar and Padam of Adi tribe of Arunachal Pradesh, India. The analyzed markers exhibited a high degree of polymorphism in the studied populations. Statistical parameters of forensic interest; observed heterozygosity, probability of homozygosity, exact test, likelihood ratio test, power of discrimination, power of exclusion, match probability and typical paternity index were determined for all loci. The average heterozygosity values were found to be low in the three populations (Panggi: 0.7747; Komkar: 0.7742 and Padam: 0.7663). The combined power of discrimination and power of exclusion were 0.9999 in the studied populations thereby revealing the high forensic significance of the chosen markers. The study indicates the utility of the tested microsatellite markers in forensic human identification, paternity testing and human population genetic studies.
对印度阿鲁纳恰尔邦阿迪部落的三个偏远、孤立的讲藏缅语的子部落(即庞吉、科姆卡尔和帕丹)的223名健康个体,分析了15个常染色体STR基因座。所分析的标记在研究人群中表现出高度多态性。确定了所有基因座的法医相关统计参数:观察杂合度、纯合概率、确切检验、似然比检验、鉴别力、排除力、匹配概率和典型父权指数。发现这三个人群的平均杂合度值较低(庞吉:0.7747;科姆卡尔:0.7742;帕丹:0.7663)。在研究人群中,鉴别力和排除力的联合值为0.9999,从而揭示了所选标记的高度法医意义。该研究表明,所测试的微卫星标记在法医人类识别、亲子鉴定和人类群体遗传学研究中具有实用性。