浙江省（中国东南部）人群中15个短串联重复序列（STR）位点的遗传分析。
Genetic analysis of 15 STR loci in the population of Zhejiang Province (Southeast China).
作者信息
Zhu Yuning, Lu Shiming, Xie Zhenwei, Chen Yan, You Jianfei
机构信息
Women's Hospital, School of Medicine, Zhejiang University, Hangzhou 310006, Zhejiang, China.
出版信息
Forensic Sci Int Genet. 2009 Sep;3(4):e139-40. doi: 10.1016/j.fsigen.2008.11.006. Epub 2008 Dec 25.
Fifteen autosomal STR loci were analyzed from a population sample of 598 unrelated individuals residing in Zhejiang Province. We report allele frequencies distribution and statistical parameters for all 15 STR loci, D8S1179, D21S11, D7S820, CSF1PO, D3S1358, THO1, D13S317, D16S539, D2S1338, D19S433, VWA, TPOX, D18S51, D5S818 and FGA. Allele frequencies, the observed heterozygosity (Ho), the polymorphic information content (PIC), and the probability of paternity exclusion (PE) were calculated. All loci were in accordance with Hardy-Weinberg equilibrium (P>0.05). Our studied population data were compared with the previously published population data of other ethnic groups or areas in China. Our results of present study were valuable for human identification and paternity tests in Zhejiang Province.
对来自浙江省598名无亲缘关系个体的群体样本分析了15个常染色体STR基因座。我们报告了所有15个STR基因座（D8S1179、D21S11、D7S820、CSF1PO、D3S1358、THO1、D13S317、D16S539、D2S1338、D19S433、VWA、TPOX、D18S51、D5S818和FGA）的等位基因频率分布及统计参数。计算了等位基因频率、观察杂合度（Ho）、多态信息含量（PIC）和排除父权概率（PE）。所有基因座均符合哈迪-温伯格平衡（P>0.05）。将我们研究的群体数据与之前发表的中国其他民族或地区的群体数据进行了比较。本研究结果对浙江省的人类身份鉴定和亲子鉴定具有重要价值。
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