Utevsky A M, Osynska V O
Ukr Biokhim Zh. 1975 Nov-Dec;47(6):683-95.
On the basis of the authors and their collaborators studies and the data of other investigators, the paper deals with significance and development of the idea of the role in the regulation of the processes and functions not only of unchanged adrenergic hormones-mediators (catecholamines) but also of the products of their metabolism as well as of those ways by which this metabolism occurs. Diversity in the processes of catecholamines and other hormones transformation makes it possible the shunting of this metabolism from one ways to others, that has an effect on many key enzymes of the intracellular metabolism. The products of quinoid and monoaminoxidase transformation of catecholamines affect directly the enzymatic processes and may change the character and intensity of the subsequent and simultaneous effect of the native hormones-mediators. The data obtained when studying adrenaline and noradrenaline metabolism may be extrapolated to certain aspects of the action mechanism of other hormones and mediators of nervous processes. An attempt is made to generalize theoretically the data on the role of hormones-mediators of metabolism in the mechanism of their action with the idea of "induced fit" of the enzymes and with certain problems of biochemistry of the effector cells receptors.
