血清肝细胞生长因子作为头颈部鳞状细胞癌肿瘤活性的标志物。

Serum hepatocyte growth factor as a marker of tumor activity in head and neck squamous cell carcinoma.

作者信息

Kim Chul-Ho, Lee Jin Seok, Kang Sung-Ook, Bae Joon-Ho, Hong Sung Pyo, Kahng Hison

机构信息

Department of Otolaryngology, School of Medicine, Ajou University, 5 Wonchon-Dong, Yeongtong-Gu, Suwon 442-749, Republic of Korea.

出版信息

Oral Oncol. 2007 Nov;43(10):1021-5. doi: 10.1016/j.oraloncology.2006.11.016. Epub 2007 Feb 15.

DOI:10.1016/j.oraloncology.2006.11.016

PMID:17306605

Abstract

Hepatocyte growth factor (HGF) has previously been reported to be elevated in the serum of patients with malignancy, including breast, colorectal and gastric cancers. Here, we evaluated the correlation between serum HGF and the progression of head and neck squamous cell carcinoma (HNSCC). The mean serum HGF levels in 71 healthy control subjects, 78 patients with primary HNSCC, and eight patients with recurrent HNSCC were 0.538+/-0.163, 0.701+/-0.252, and 0.925+/-0.349ng/ml, respectively. The increase in the HGF level was significantly correlated with tumor stage progression. The HGF level had decreased to normal at 1 month after curative resection of the tumors. During follow-up for several months, the HGF level significantly increased in recurrent HNSCC patients, whereas there was no increase in nonrecurrent patients. Our data suggest that serum HGF is significantly corrected with tumor progression and may be a strong predictor of recurrence in HNSCC.

摘要

肝细胞生长因子（HGF）此前有报道称，在包括乳腺癌、结直肠癌和胃癌在内的恶性肿瘤患者血清中水平会升高。在此，我们评估了血清HGF与头颈部鳞状细胞癌（HNSCC）进展之间的相关性。71名健康对照者、78例原发性HNSCC患者和8例复发性HNSCC患者的血清HGF平均水平分别为0.538±0.163、0.701±0.252和0.925±0.349ng/ml。HGF水平的升高与肿瘤分期进展显著相关。肿瘤根治性切除术后1个月，HGF水平已降至正常。在数月的随访期间，复发性HNSCC患者的HGF水平显著升高，而非复发性患者则无升高。我们的数据表明，血清HGF与肿瘤进展显著相关，可能是HNSCC复发的有力预测指标。