Wang Haiying, Yang Liqian, Liu Minghui, Luo Jianyuan
Beijing Key Laboratory of Protein Posttranslational Modifications and Cell Function, Department of Biochemistry and Biophysics, School of Basic Medical Sciences, Peking University Health Science Center, 100191, Beijing, China.
Department of Medical Genetics, Center for Medical Genetics, Peking University Health Science Center, 100191, Beijing, China.
Cancer Gene Ther. 2023 Apr;30(4):529-547. doi: 10.1038/s41417-022-00464-3. Epub 2022 Apr 7.
Posttranslational modifications (PTMs) of proteins, the major mechanism of protein function regulation, play important roles in regulating a variety of cellular physiological and pathological processes. Although the classical PTMs, such as phosphorylation, acetylation, ubiquitination and methylation, have been well studied, the emergence of many new modifications, such as succinylation, hydroxybutyrylation, and lactylation, introduces a new layer to protein regulation, leaving much more to be explored and wide application prospects. In this review, we will provide a broad overview of the significant roles of PTMs in regulating human cancer hallmarks through selecting a diverse set of examples, and update the current advances in the therapeutic implications of these PTMs in human cancer.
蛋白质的翻译后修饰（PTMs）是蛋白质功能调控的主要机制，在调节多种细胞生理和病理过程中发挥着重要作用。尽管经典的翻译后修饰，如磷酸化、乙酰化、泛素化和甲基化，已经得到了深入研究，但许多新的修饰，如琥珀酰化、羟基丁酰化和乳酰化的出现，为蛋白质调控增添了新的层面，仍有许多有待探索之处，且具有广阔的应用前景。在本综述中，我们将通过选取一系列不同的例子，广泛概述翻译后修饰在调控人类癌症特征中的重要作用，并更新这些翻译后修饰在人类癌症治疗意义方面的当前进展。
