受体酪氨酸激酶：激活与信号传导机制
Receptor tyrosine kinases: mechanisms of activation and signaling.
作者信息
Hubbard Stevan R, Miller W Todd
机构信息
Skirball Institute of Biomolecular Medicine and Department of Pharmacology, New York University School of Medicine, New York, NY 10016, USA.
出版信息
Curr Opin Cell Biol. 2007 Apr;19(2):117-23. doi: 10.1016/j.ceb.2007.02.010. Epub 2007 Feb 16.
Abstract
Receptor tyrosine kinases (RTKs) are essential components of signal transduction pathways that mediate cell-to-cell communication. These single-pass transmembrane receptors, which bind polypeptide ligands - mainly growth factors - play key roles in processes such as cellular growth, differentiation, metabolism and motility. Recent progress has been achieved towards an understanding of the precise (and varied) mechanisms by which RTKs are activated by ligand binding and by which signals are propagated from the activated receptors to downstream targets in the cell.
摘要
受体酪氨酸激酶（RTKs）是介导细胞间通讯的信号转导通路的重要组成部分。这些单次跨膜受体可结合多肽配体——主要是生长因子——在细胞生长、分化、代谢和运动等过程中发挥关键作用。在理解RTKs通过配体结合被激活以及信号从激活的受体传递到细胞内下游靶点的精确（且多样）机制方面，已取得了最新进展。
相似文献
1
Receptor tyrosine kinases: mechanisms of activation and signaling.受体酪氨酸激酶：激活与信号传导机制
Curr Opin Cell Biol. 2007 Apr;19(2):117-23. doi: 10.1016/j.ceb.2007.02.010. Epub 2007 Feb 16.
2
Autoinhibitory mechanisms in receptor tyrosine kinases.受体酪氨酸激酶中的自抑制机制。
Front Biosci. 2002 Feb 1;7:d330-40. doi: 10.2741/A778.
3
Cross-talk between RON receptor tyrosine kinase and other transmembrane receptors.RON受体酪氨酸激酶与其他跨膜受体之间的相互作用。
Histol Histopathol. 2001 Apr;16(2):623-31. doi: 10.14670/HH-16.623.
4
Signal transduction pathways of G protein-coupled receptors and their cross-talk with receptor tyrosine kinases: lessons from bradykinin signaling.G蛋白偶联受体的信号转导途径及其与受体酪氨酸激酶的相互作用：缓激肽信号转导的启示
Curr Med Chem. 2000 Sep;7(9):911-43. doi: 10.2174/0929867003374589.
5
Structural analysis of receptor tyrosine kinases.受体酪氨酸激酶的结构分析
Prog Biophys Mol Biol. 1999;71(3-4):343-58. doi: 10.1016/s0079-6107(98)00047-9.
6
Crosstalk coregulation mechanisms of G protein-coupled receptors and receptor tyrosine kinases.G蛋白偶联受体与受体酪氨酸激酶的相互作用协同调控机制
Methods Mol Biol. 2006;332:51-77. doi: 10.1385/1-59745-048-0:51.
7
Cell communication networks: epidermal growth factor receptor transactivation as the paradigm for interreceptor signal transmission.细胞通讯网络：以表皮生长因子受体反式激活作为受体间信号传递的范例
Oncogene. 2001 Mar 26;20(13):1594-600. doi: 10.1038/sj.onc.1204192.
8
Receptor tyrosine kinase activation: From the ligand perspective.受体酪氨酸激酶激活：从配体角度看。
Curr Opin Cell Biol. 2020 Apr;63:174-185. doi: 10.1016/j.ceb.2020.01.016. Epub 2020 Feb 27.
9
Cell signaling by receptor tyrosine kinases.受体酪氨酸激酶介导的细胞信号传导
Cell. 2000 Oct 13;103(2):211-25. doi: 10.1016/s0092-8674(00)00114-8.
10
Cell signaling by receptor tyrosine kinases.受体酪氨酸激酶的细胞信号转导。
Cell. 2010 Jun 25;141(7):1117-34. doi: 10.1016/j.cell.2010.06.011.
引用本文的文献
1
High-throughput discovery of transmembrane helix dimers from human single-pass membrane proteins with TOXGREEN sort-seq.利用TOXGREEN分选测序技术从人类单次跨膜蛋白中高通量发现跨膜螺旋二聚体。
bioRxiv. 2025 May 11:2025.04.22.650048. doi: 10.1101/2025.04.22.650048.
2
RTK_RAG: Leveraging Retrieval Augmented Generation with Multi-Window Convolutional Neural Networks for Superior ATP Binding Site Prediction in Receptor Tyrosine Kinases.RTK_RAG：利用多窗口卷积神经网络的检索增强生成技术实现受体酪氨酸激酶中ATP结合位点的卓越预测。
J Chem Inf Model. 2025 Jul 14;65(13):7277-7284. doi: 10.1021/acs.jcim.5c00766. Epub 2025 Jun 18.
3
Molecular Targets in Alveolar Rhabdomyosarcoma: A Narrative Review of Progress and Pitfalls.肺泡横纹肌肉瘤的分子靶点：进展与陷阱的叙述性综述
Int J Mol Sci. 2025 May 28;26(11):5204. doi: 10.3390/ijms26115204.
4
Decoding protein-peptide interactions using a large, target-agnostic yeast surface display library.使用一个大型的、与靶点无关的酵母表面展示文库解码蛋白质-肽相互作用。
bioRxiv. 2025 May 23:2025.05.19.654863. doi: 10.1101/2025.05.19.654863.
5
RSK2 and its binding partners: an emerging signaling node in cancers.核糖体S6激酶2（RSK2）及其结合伴侣：癌症中一个新出现的信号节点
Arch Pharm Res. 2025 May;48(5):365-383. doi: 10.1007/s12272-025-01543-3. Epub 2025 May 5.
6
Genome identification of the LRR-RLK gene family in maize (Zea mays) and expression analysis in response to Fusarium verticillioides infection.玉米（Zea mays）中LRR-RLK基因家族的基因组鉴定及对轮枝镰孢菌感染的表达分析。
BMC Plant Biol. 2025 Apr 25;25(1):524. doi: 10.1186/s12870-025-06495-w.
7
Emerging Therapeutic Targets in Rheumatoid Arthritis: Focusing on HIF-1α, Nrf2, STATs, and RORγt.类风湿关节炎中新出现的治疗靶点：聚焦于缺氧诱导因子-1α、核因子E2相关因子2、信号转导和转录激活因子以及维甲酸相关孤儿受体γt
Curr Drug Targets. 2025;26(8):507-533. doi: 10.2174/0113894501372670250408074908.
8
Single-molecule localization microscopy as a tool to quantify di/oligomerization of receptor tyrosine kinases and G protein-coupled receptors.单分子定位显微镜作为一种量化受体酪氨酸激酶和G蛋白偶联受体二聚化/寡聚化的工具。
Mol Pharmacol. 2025 May;107(5):100033. doi: 10.1016/j.molpha.2025.100033. Epub 2025 Mar 26.
9
The state of targeted therapeutic pharmacological approaches in pediatric neurosurgery: report from the European Society for Pediatric Neurosurgery (ESPN) Consensus Conference 2024.小儿神经外科靶向治疗药理学方法的现状：来自欧洲小儿神经外科学会（ESPN）2024年共识会议的报告
Childs Nerv Syst. 2025 Apr 2;41(1):149. doi: 10.1007/s00381-025-06799-0.
10
An Alternative Mode of GPCR Transactivation: Activation of GPCRs by Adhesion GPCRs.G蛋白偶联受体（GPCR）反式激活的另一种模式：黏附性GPCR对GPCR的激活
Int J Mol Sci. 2025 Jan 10;26(2):552. doi: 10.3390/ijms26020552.
本文引用的文献
1
A phosphoproteomic analysis of the ErbB2 receptor tyrosine kinase signaling pathways.表皮生长因子受体2（ErbB2）受体酪氨酸激酶信号通路的磷酸化蛋白质组学分析
Biochemistry. 2006 Dec 26;45(51):15529-40. doi: 10.1021/bi060971c. Epub 2006 Dec 19.
2
Functional and quantitative proteomics using SILAC.使用稳定同位素标记氨基酸法进行功能和定量蛋白质组学研究。
Nat Rev Mol Cell Biol. 2006 Dec;7(12):952-8. doi: 10.1038/nrm2067.
3
A functional RNAi screen for regulators of receptor tyrosine kinase and ERK signalling.针对受体酪氨酸激酶和ERK信号通路调节因子的功能性RNA干扰筛选。
Nature. 2006 Nov 9;444(7116):230-4. doi: 10.1038/nature05280. Epub 2006 Nov 1.
4
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks.信号网络中的全局、体内及位点特异性磷酸化动力学
Cell. 2006 Nov 3;127(3):635-48. doi: 10.1016/j.cell.2006.09.026.
5
Presenilin-dependent ErbB4 nuclear signaling regulates the timing of astrogenesis in the developing brain.早老素依赖的ErbB4核信号传导调节发育中大脑星形胶质细胞生成的时间。
Cell. 2006 Oct 6;127(1):185-97. doi: 10.1016/j.cell.2006.07.037.
6
Quantitative analysis of the activation mechanism of the multicomponent growth-factor receptor Ret.多组分生长因子受体Ret激活机制的定量分析
Nat Chem Biol. 2006 Nov;2(11):636-44. doi: 10.1038/nchembio823. Epub 2006 Oct 1.
7
Crystal structure of the agrin-responsive immunoglobulin-like domains 1 and 2 of the receptor tyrosine kinase MuSK.受体酪氨酸激酶MuSK的聚集蛋白反应性免疫球蛋白样结构域1和2的晶体结构
J Mol Biol. 2006 Dec 1;364(3):424-33. doi: 10.1016/j.jmb.2006.09.019. Epub 2006 Sep 12.
8
Structure of the insulin receptor ectodomain reveals a folded-over conformation.胰岛素受体胞外域的结构显示出一种折叠构象。
Nature. 2006 Sep 14;443(7108):218-21. doi: 10.1038/nature05106. Epub 2006 Sep 6.
9
Single-molecule analysis of epidermal growth factor binding on the surface of living cells.活细胞表面表皮生长因子结合的单分子分析。
EMBO J. 2006 Sep 20;25(18):4215-22. doi: 10.1038/sj.emboj.7601308. Epub 2006 Aug 31.
10
Quantitative multiplexed profiling of cellular signaling networks using phosphotyrosine-specific DNA-tagged SH2 domains.使用磷酸酪氨酸特异性DNA标记的SH2结构域对细胞信号网络进行定量多重分析。
Nat Methods. 2006 Sep;3(9):737-44. doi: 10.1038/nmeth917.
Zotero 插件