Yamamoto Hitoshi, Murakami Hiroshi, Kamiyama Noriko, Miyamoto Yusaku, Fukuda Miho
Department of Pediatrics, St. Marianna University, School of Medicine, 2-16-1 Sugao, Miyamae-ku, Kawasaki 216-8511, Kanagawa, Japan.
Brain Dev. 2007 Sep;29(8):468-72. doi: 10.1016/j.braindev.2006.12.009. Epub 2007 Feb 20.
We describe a peculiar form of epilepsy following prolonged and vigorous bouts of crying in infancy which was misdiagnosed as breath holding spells. Three patients with crying-induced epilepsy had the following characteristics. The patients were born after uncomplicated pregnancy, labor, and delivery. The seizures presented between the ages of 10 and 18 months, the patients had normal development and cranial MRIs, no past or family histories of epilepsy or cardiac disease, and developed generalized tonic clonic seizures only following crying after a sudden, unexpected and mildly unpleasant stimulus. The seizures usually lasted no longer than 1 min and their EEG showed focal spikes in interictal states and generalized spikes in ictal states. The seizures were well controlled with valproate sodium. This peculiar form of epilepsy may be a benign age-dependent reflex epilepsy in infancy.
我们描述了一种特殊形式的癫痫，其发生于婴儿期长时间剧烈哭闹之后，曾被误诊为屏气发作。三名哭闹诱发癫痫的患者具有以下特征。这些患者出生时妊娠、分娩过程均无并发症。癫痫发作于10至18个月龄之间，患者发育正常，头颅MRI检查正常，既往及家族均无癫痫或心脏病史，仅在突然、意外且轻微不愉快的刺激后哭闹时出现全身强直阵挛发作。发作通常持续不超过1分钟，脑电图显示发作间期局灶性棘波，发作期广泛性棘波。丙戊酸钠能很好地控制发作。这种特殊形式的癫痫可能是婴儿期一种良性的年龄依赖性反射性癫痫。
