In vivo fluorescent imaging of the mouse retina using adaptive optics.
作者信息
Biss David P, Sumorok Daniel, Burns Stephen A, Webb Robert H, Zhou Yaopeng, Bifano Thomas G, Côté Daniel, Veilleux Israel, Zamiri Parisa, Lin Charles P
机构信息
Schepens Eye Research Institute, Boston, Massachusetts 02114, USA.
出版信息
Opt Lett. 2007 Mar 15;32(6):659-61. doi: 10.1364/ol.32.000659.
Abstract
In vivo imaging of the mouse retina using visible and near infrared wavelengths does not achieve diffraction-limited resolution due to wavefront aberrations induced by the eye. Considering the pupil size and axial dimension of the eye, it is expected that unaberrated imaging of the retina would have a transverse resolution of 2 microm. Higher-order aberrations in retinal imaging of human can be compensated for by using adaptive optics. We demonstrate an adaptive optics system for in vivo imaging of fluorescent structures in the retina of a mouse, using a microelectromechanical system membrane mirror and a Shack-Hartmann wavefront sensor that detects fluorescent wavefront.
摘要
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