Park Jung-Hoon, Kong Lingjie, Zhou Yifeng, Cui Meng
School of Electrical and Computer Engineering, Purdue University, West Lafayette, Indiana, USA.
Department of Biological Sciences, Purdue University, West Lafayette, Indiana, USA.
Nat Methods. 2017 Jun;14(6):581-583. doi: 10.1038/nmeth.4290. Epub 2017 May 8.
Adaptive optics can correct for optical aberrations. We developed multi-pupil adaptive optics (MPAO), which enables simultaneous wavefront correction over a field of view of 450 × 450 μm and expands the correction area to nine times that of conventional methods. MPAO's ability to perform spatially independent wavefront control further enables 3D nonplanar imaging. We applied MPAO to in vivo structural and functional imaging in the mouse brain.
自适应光学能够校正光学像差。我们开发了多瞳孔自适应光学（MPAO）技术，它能够在450×450μm的视场内同时进行波前校正，并将校正面积扩大到传统方法的九倍。MPAO进行空间独立波前控制的能力进一步实现了三维非平面成像。我们将MPAO应用于小鼠大脑的活体结构和功能成像。
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