Tso Tim K, Huang Wen-Nan
Graduate Institute of Food Science, National Chiayi University, Taiwan, ROC.
J Rheumatol. 2007 Apr;34(4):726-30.
Intracellular adhesion molecule-1 (ICAM-1) and vascular cell adhesion molecule-1 (VCAM-1) are members of the immunoglobulin supergene family and play a central role in cell-to-cell and in cell-to-extracellular matrix-mediated immune responses. Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by a wide variety of immunological abnormalities. The relationship between soluble adhesion molecules and insulin resistance has been observed in different populations. However, the association of circulating levels of soluble cell adhesion molecules with insulin resistance and/or hyperinsulinemia in patients with SLE has not been extensively established.
We evaluated the relationship of soluble ICAM-1 (sICAM-1) and VCAM-1 (sVCAM-1) to insulin resistance in 68 patients with SLE and 34 age-matched healthy controls.
Patients with SLE had significantly higher fasting insulin levels, homeostasis model assessment insulin resistance (HOMA-IR), HOMA beta-cell, and plasma levels of sICAM-1 and sVCAM-1 than controls. SLE patients with HOMA-IR in the top quartile had the highest plasma levels of sICAM-1. However, there was no statistical difference in plasma levels of sVCAM-1 between patients in the respective quartiles of insulin sensitivity-related variables. Plasma levels of sICAM-1, but not sVCAM-1, were significantly correlated with fasting insulin (r = 0.327, p = 0.006), HOMA-IR (r = 0.278, p = 0.022), and HOMA beta-cell (r = 0.359, p = 0.003). In addition, fasting insulin was responsible for sICAM-1 variability in patients with SLE.
The elevation of plasma levels of sICAM-1 was associated with a status of insulin resistance in patients with SLE.
细胞间黏附分子-1（ICAM-1）和血管细胞黏附分子-1（VCAM-1）是免疫球蛋白超基因家族的成员，在细胞间以及细胞与细胞外基质介导的免疫反应中起核心作用。系统性红斑狼疮（SLE）是一种慢性自身免疫性疾病，其特征为多种免疫异常。在不同人群中已观察到可溶性黏附分子与胰岛素抵抗之间的关系。然而，SLE患者循环中可溶性细胞黏附分子水平与胰岛素抵抗和/或高胰岛素血症之间的关联尚未得到广泛证实。
我们评估了68例SLE患者和34例年龄匹配的健康对照中可溶性ICAM-1（sICAM-1）和VCAM-1（sVCAM-1）与胰岛素抵抗的关系。
SLE患者的空腹胰岛素水平、稳态模型评估胰岛素抵抗（HOMA-IR）、HOMAβ细胞以及sICAM-1和sVCAM-1的血浆水平均显著高于对照组。HOMA-IR处于最高四分位数的SLE患者，其sICAM-1的血浆水平最高。然而，胰岛素敏感性相关变量各四分位数的患者之间，sVCAM-1的血浆水平无统计学差异。sICAM-1而非sVCAM-1的血浆水平与空腹胰岛素（r = 0.327，p = 0.006）、HOMA-IR（r = 0.278，p = 0.022）和HOMAβ细胞（r = 0.359，p = 0.003）显著相关。此外，空腹胰岛素是SLE患者sICAM-1变异性的原因。
SLE患者血浆sICAM-1水平升高与胰岛素抵抗状态相关。
